trans-Resveratrol-3-O-β-D-Glucuronide 

trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers^[1][2][3].

trans-Resveratrol-3-O-β-D-Glucuronide (48 h) inhibits cell growth with the IC₅₀ valus of 15.8 μM, 16.5 μM and 10.1 μM against CCL-228, Caco-2 and HCT-116 cells, respectively^[2].
trans-Resveratrol-3-O-β-D-Glucuronide (30 μM, 48 h) induces S phase arrest in CCL-228, Caco-2 and HCT-116 cells^[2].
trans-Resveratrol-3-O-β-D-Glucuronide (200 μM, 10 mins) increases pyruvate production in livers isolated from rats in a model of arthritis induced by complete Freund's adjuvant^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

404.37

C₂₀H₂₀O₉

387372-17-0

Solid

Off-white to light yellow

OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC(/C=C/C3=CC=C(C=C3)O)=CC(O)=C2)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Rousova J, et al. Determination of trans-resveratrol and its metabolites in rat serum using liquid chromatography with high-resolution time of flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1039:35-43.  [Content Brief]

  [2]. Polycarpou E, et al. Resveratrol 3-O-D-glucuronide and resveratrol 4'-O-D-glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. Mol Nutr Food Res. 2013;57(10):1708-1717.  [Content Brief]

  [3]. Simões MS, et al. Resveratrol biotransformation and actions on the liver metabolism of healthy and arthritic rats. Life Sci. 2022;310:120991.  [Content Brief]