TRC-766

Cat. No.: HY-131443 Purity: 99.75%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase.

For research use only. We do not sell to patients.

TRC-766 Chemical Structure

CAS No. : 1810734-44-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 254	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 254	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase^[1].

In Vitro

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

524.98

Formula

C₂₅H₂₄ClF₃N₂O₃S

CAS No.

1810734-44-1

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N(CCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL (285.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9048 mL	9.5242 mL	19.0483 mL
5 mM	0.3810 mL	1.9048 mL	3.8097 mL
10 mM	0.1905 mL	0.9524 mL	1.9048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (251 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9048 mL	9.5242 mL	19.0483 mL	47.6209 mL
	5 mM	0.3810 mL	1.9048 mL	3.8097 mL	9.5242 mL
	10 mM	0.1905 mL	0.9524 mL	1.9048 mL	4.7621 mL
	15 mM	0.1270 mL	0.6349 mL	1.2699 mL	3.1747 mL
	20 mM	0.0952 mL	0.4762 mL	0.9524 mL	2.3810 mL
	25 mM	0.0762 mL	0.3810 mL	0.7619 mL	1.9048 mL
	30 mM	0.0635 mL	0.3175 mL	0.6349 mL	1.5874 mL
	40 mM	0.0476 mL	0.2381 mL	0.4762 mL	1.1905 mL
	50 mM	0.0381 mL	0.1905 mL	0.3810 mL	0.9524 mL
	60 mM	0.0317 mL	0.1587 mL	0.3175 mL	0.7937 mL
	80 mM	0.0238 mL	0.1191 mL	0.2381 mL	0.5953 mL
	100 mM	0.0190 mL	0.0952 mL	0.1905 mL	0.4762 mL

TRC-766 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRC-7661810734-44-1TRC766TRC 766PhosphataseTRC-382negativecontrolPP2AInhibitorinhibitorinhibit

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