Trimazosin

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Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors.

For research use only. We do not sell to patients.

Trimazosin Chemical Structure

CAS No. : 35795-16-5

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Other Forms of Trimazosin:

Trimazosin hydrochloride hydrate Get quote

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α adrenergic receptor β adrenergic receptor

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Description

Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors^[1]^[2].

IC₅₀ & Target

α1-adrenergic receptor

In Vivo

Trimazosin (10–30 mg/kg; i.h.; once) produces graded decreases in blood pressure^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious spontaneously hypertensive rats (SHR)^[3]
Dosage:	10–30 mg/kg
Administration:	Subcutaneous administration, once
Result:	Produced graded decreases in blood pressure.

Molecular Weight

435.47

Formula

C₂₀H₂₉N₅O₆

CAS No.

35795-16-5

SMILES

O=C(N1CCN(CC1)C2=NC3=C(C=C(C(OC)=C3OC)OC)C(N)=N2)OCC(C)(C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. J Vincent, et al. The cardiovascular effects of trimazosin and prazosin in the rabbit. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):593-608. [Content Brief]

[2]. H L Elliott, et al. Trimazosin in normotensive subjects. Clin Pharmacol Ther. 1984 Feb;35(2):156-60. [Content Brief]

[3]. J. P. Buyniski, et al. Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat. Clinical and Experimental Hypertension , 1980, Vol.2(6), p.1039-1066. [Content Brief]

Trimazosin Related Classifications

Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimazosin35795-16-5Adrenergic ReceptorBeta ReceptorQuinazoline derivativePrazosinHypotensive effectInhibitorinhibitorinhibit

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