2. Cell Cycle/DNA Damage Anti-infection
  3. Antifolate Bacterial Antibiotic
  4. Trimethoprim-d3

Trimethoprim-d3is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

For research use only. We do not sell to patients.

Trimethoprim-d<sub>3</sub> Chemical Structure

Trimethoprim-d3 Chemical Structure

CAS No. : 1189923-38-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Trimethoprim-d3:

Trimethoprim-d3 Related Antibodies

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Description

Trimethoprim-d3is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trimethoprim-d3 Related Antibodies
Molecular Weight

293.34

Formula

C14H15D3N4O3
CAS No.
Unlabeled CAS

738-70-5
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1CC2=CN=C(N)N=C2N)=C(C(OC)=C1)OC([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (170.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (170.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.67 mg/mL (2.28 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4090 mL 17.0451 mL 34.0901 mL
5 mM 0.6818 mL 3.4090 mL 6.8180 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 3.4090 mL 17.0451 mL 34.0901 mL 85.2253 mL
DMSO / DMSO 5 mM 0.6818 mL 3.4090 mL 6.8180 mL 17.0451 mL
10 mM 0.3409 mL 1.7045 mL 3.4090 mL 8.5225 mL
15 mM 0.2273 mL 1.1363 mL 2.2727 mL 5.6817 mL
20 mM 0.1705 mL 0.8523 mL 1.7045 mL 4.2613 mL
25 mM 0.1364 mL 0.6818 mL 1.3636 mL 3.4090 mL
30 mM 0.1136 mL 0.5682 mL 1.1363 mL 2.8408 mL
40 mM 0.0852 mL 0.4261 mL 0.8523 mL 2.1306 mL
50 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7045 mL
60 mM 0.0568 mL 0.2841 mL 0.5682 mL 1.4204 mL
80 mM 0.0426 mL 0.2131 mL 0.4261 mL 1.0653 mL
100 mM 0.0341 mL 0.1705 mL 0.3409 mL 0.8523 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Trimethoprim-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimethoprim-d31189923-38-3AntifolateBacterialAntibioticInhibitorinhibitorinhibit

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