2. Immunology/Inflammation NF-κB Stem Cell/Wnt TGF-beta/Smad Metabolic Enzyme/Protease
  3. NOD-like Receptor (NLR) Reactive Oxygen Species TGF-beta/Smad Endogenous Metabolite
  4. Trimethylamine N-oxide-d9

Trimethylamine N-oxide-d9 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

For research use only. We do not sell to patients.

Trimethylamine N-oxide-d<sub>9</sub> Chemical Structure

Trimethylamine N-oxide-d9 Chemical Structure

CAS No. : 1161070-49-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Trimethylamine N-oxide-d9:

Trimethylamine N-oxide-d9 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Trimethylamine N-oxide-d9

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NLRP3 NLRP1 NOD1 NOD2

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Description

Trimethylamine N-oxide-d9 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trimethylamine N-oxide-d9 Related Antibodies
Molecular Weight

84.17

Formula

C3D9NO
CAS No.
Unlabeled CAS

1184-78-7
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([N+](C([2H])([2H])[2H])([O-])C([2H])([2H])[2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1188.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (1188.07 mM; Need ultrasonic)

H2O : 100 mg/mL (1188.07 mM; Need ultrasonic)

DMSO : 100 mg/mL (1188.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.8807 mL 59.4036 mL 118.8072 mL
5 mM 2.3761 mL 11.8807 mL 23.7614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O / H2O / DMSO 1 mM 11.8807 mL 59.4036 mL 118.8072 mL 297.0179 mL
5 mM 2.3761 mL 11.8807 mL 23.7614 mL 59.4036 mL
10 mM 1.1881 mL 5.9404 mL 11.8807 mL 29.7018 mL
15 mM 0.7920 mL 3.9602 mL 7.9205 mL 19.8012 mL
20 mM 0.5940 mL 2.9702 mL 5.9404 mL 14.8509 mL
25 mM 0.4752 mL 2.3761 mL 4.7523 mL 11.8807 mL
30 mM 0.3960 mL 1.9801 mL 3.9602 mL 9.9006 mL
40 mM 0.2970 mL 1.4851 mL 2.9702 mL 7.4254 mL
50 mM 0.2376 mL 1.1881 mL 2.3761 mL 5.9404 mL
60 mM 0.1980 mL 0.9901 mL 1.9801 mL 4.9503 mL
80 mM 0.1485 mL 0.7425 mL 1.4851 mL 3.7127 mL
100 mM 0.1188 mL 0.5940 mL 1.1881 mL 2.9702 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Trimethylamine N-oxide-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimethylamine N-oxide-d91161070-49-0NOD-like Receptor (NLR)Reactive Oxygen SpeciesTGF-beta/SmadEndogenous MetaboliteTransforming growth factor betaInhibitorinhibitorinhibit

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