2. Others NF-κB Apoptosis
  3. Isotope-Labeled Compounds NF-κB Apoptosis
  4. Triptolide-d3

Triptolide-d3 is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].

For research use only. We do not sell to patients.

Triptolide-d<sub>3</sub> Chemical Structure

Triptolide-d3 Chemical Structure

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Other Forms of Triptolide-d3:

Triptolide-d3 Related Antibodies

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Description

Triptolide-d3 is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triptolide-d3 Related Antibodies
Molecular Weight

363.42

Formula

C20H21D3O6
Unlabeled CAS

38748-32-2
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@]34[C@]5([C@@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)C)O)[C@@](C[C@@]1([2H])C7=C(C(OC7([2H])[2H])=O)CC2)([H])O5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (68.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7516 mL 13.7582 mL 27.5164 mL
5 mM 0.5503 mL 2.7516 mL 5.5033 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7516 mL 13.7582 mL 27.5164 mL 68.7909 mL
5 mM 0.5503 mL 2.7516 mL 5.5033 mL 13.7582 mL
10 mM 0.2752 mL 1.3758 mL 2.7516 mL 6.8791 mL
15 mM 0.1834 mL 0.9172 mL 1.8344 mL 4.5861 mL
20 mM 0.1376 mL 0.6879 mL 1.3758 mL 3.4395 mL
25 mM 0.1101 mL 0.5503 mL 1.1007 mL 2.7516 mL
30 mM 0.0917 mL 0.4586 mL 0.9172 mL 2.2930 mL
40 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7198 mL
50 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3758 mL
60 mM 0.0459 mL 0.2293 mL 0.4586 mL 1.1465 mL
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Triptolide-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triptolide-d3PG490-d3Isotope-Labeled CompoundsNF-κBApoptosisNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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