Tris(2-chloroethyl)phosphate-d₁₂ (Synonyms: TCEP-d₁₂)

Cat. No.: HY-107859S Purity: 99.15%: FAQs
Data Sheet SDS COA Handling Instructions

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Tris(2-chloroethyl)phosphate-d₁₂ is the deuterium labeled Tris(β-chloroethyl) phosphate[1].

For research use only. We do not sell to patients.

Tris(2-chloroethyl)phosphate-d<sub>12</sub> Chemical Structure

Tris(2-chloroethyl)phosphate-d₁₂ Chemical Structure

CAS No. : 1276500-47-0

Size	Price	Stock	Quantity
1 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Other Forms of Tris(2-chloroethyl)phosphate-d₁₂:

Tris(2-chloroethyl) phosphate Get quote

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Description

Tris(2-chloroethyl)phosphate-d₁₂ is the deuterium labeled Tris(β-chloroethyl) phosphate[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.56

Formula

C₆D₁₂Cl₃O₄P

CAS No.

1276500-47-0

Unlabeled CAS

115-96-8

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

ClC([2H])([2H])C([2H])([2H])OP(OC([2H])([2H])C([2H])([2H])Cl)(OC([2H])([2H])C([2H])([2H])Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 100 mg/mL (336.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3607 mL	16.8033 mL	33.6067 mL
5 mM	0.6721 mL	3.3607 mL	6.7213 mL
10 mM	0.3361 mL	1.6803 mL	3.3607 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.15%

Select Batch:

Data Sheet (278 KB) SDS (701 KB)

COA (258 KB) HNMR (452 KB) GC (466 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	3.3607 mL	16.8033 mL	33.6067 mL	84.0167 mL
	5 mM	0.6721 mL	3.3607 mL	6.7213 mL	16.8033 mL
	10 mM	0.3361 mL	1.6803 mL	3.3607 mL	8.4017 mL
	15 mM	0.2240 mL	1.1202 mL	2.2404 mL	5.6011 mL
	20 mM	0.1680 mL	0.8402 mL	1.6803 mL	4.2008 mL
	25 mM	0.1344 mL	0.6721 mL	1.3443 mL	3.3607 mL
	30 mM	0.1120 mL	0.5601 mL	1.1202 mL	2.8006 mL
	40 mM	0.0840 mL	0.4201 mL	0.8402 mL	2.1004 mL
	50 mM	0.0672 mL	0.3361 mL	0.6721 mL	1.6803 mL
	60 mM	0.0560 mL	0.2801 mL	0.5601 mL	1.4003 mL
	80 mM	0.0420 mL	0.2100 mL	0.4201 mL	1.0502 mL
	100 mM	0.0336 mL	0.1680 mL	0.3361 mL	0.8402 mL

Tris(2-chloroethyl)phosphate-d₁₂ Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tris(2-chloroethyl)phosphate-d₁₂1276500-47-0TCEP-d₁₂Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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Tris(2-chloroethyl)phosphate-d12 (Synonyms: TCEP-d12)

Other Forms of Tris(2-chloroethyl)phosphate-d12:

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Complete Stock Solution Preparation Table

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