2. Metabolic Enzyme/Protease Others
  3. Tyrosinase Others
  4. Tryptamine guanosine carbamate

Tryptamine guanosine carbamate  (Synonyms: TpGc)

Cat. No.: HY-138885 Purity: 99.79%
SDS COA Handling Instructions

Molarity Calculator

Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance.

For research use only. We do not sell to patients.

Tryptamine guanosine carbamate Chemical Structure

Tryptamine guanosine carbamate Chemical Structure

CAS No. : 1414808-96-0

Size Price Stock Quantity
5 mg USD 210 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1120 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Tryptamine guanosine carbamate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance[1].

In Vivo

Pretreatment with 20 nmol Tryptamine guanosine carbamate enhances morphine antinociception in 129 HINT1+/+ mice and is devoid of effect in HINT1-/- mice.The administration of 7 and 20 nmol of Tryptamine guanosine carbamate 20min before the morphine priming dose significantly reduces the development of acute antinociceptive tolerance in HINT1+/+ mice but not in HINT1-/- animals[1].
Tryptamine guanosine carbamate reduces the recruitment of NMDAR activity promoted by morphine. In mice suffering from chronic constriction injury concurrent with increased NMDAR activity, a single intracerebroventricular administration of Tryptamine guanosine carbamate (20 nmol) attenuates NMDAR function and alleviated mechanical allodynia for several days[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

469.45

Formula

C21H23N7O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COC(NCCC4=CNC5=CC=CC=C45)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (266.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1302 mL 10.6508 mL 21.3015 mL
5 mM 0.4260 mL 2.1302 mL 4.2603 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1302 mL 10.6508 mL 21.3015 mL 53.2538 mL
5 mM 0.4260 mL 2.1302 mL 4.2603 mL 10.6508 mL
10 mM 0.2130 mL 1.0651 mL 2.1302 mL 5.3254 mL
15 mM 0.1420 mL 0.7101 mL 1.4201 mL 3.5503 mL
20 mM 0.1065 mL 0.5325 mL 1.0651 mL 2.6627 mL
25 mM 0.0852 mL 0.4260 mL 0.8521 mL 2.1302 mL
30 mM 0.0710 mL 0.3550 mL 0.7101 mL 1.7751 mL
40 mM 0.0533 mL 0.2663 mL 0.5325 mL 1.3313 mL
50 mM 0.0426 mL 0.2130 mL 0.4260 mL 1.0651 mL
60 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8876 mL
80 mM 0.0266 mL 0.1331 mL 0.2663 mL 0.6657 mL
100 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5325 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Tryptamine guanosine carbamate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tryptamine guanosine carbamate1414808-96-0TpGcTyrosinaseOthersantinociceptionchronicconstrictioninjurymechanicalallodyniaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tryptamine guanosine carbamate
Cat. No.:
HY-138885
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.