2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. TTA-P2

TTA-P2  (Synonyms: T-Type calcium channel inhibitor)

Cat. No.: HY-10035 Purity: 99.92% ee.: 100%
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TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease.

For research use only. We do not sell to patients.

TTA-P2 Chemical Structure

TTA-P2 Chemical Structure

CAS No. : 1072018-68-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 598 In-stock
Solution
10 mM * 1 mL in DMSO USD 598 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 630 In-stock
10 mg USD 1070 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of TTA-P2:

TTA-P2 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease[1].

Molecular Weight

431.37

Formula

C21H29Cl2FN2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)(OCC1)C[C@H]1CN2CCC(F)(CC2)CNC(C3=CC(Cl)=CC(Cl)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (57.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3182 mL 11.5910 mL 23.1820 mL
5 mM 0.4636 mL 2.3182 mL 4.6364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3182 mL 11.5910 mL 23.1820 mL 57.9549 mL
5 mM 0.4636 mL 2.3182 mL 4.6364 mL 11.5910 mL
10 mM 0.2318 mL 1.1591 mL 2.3182 mL 5.7955 mL
15 mM 0.1545 mL 0.7727 mL 1.5455 mL 3.8637 mL
20 mM 0.1159 mL 0.5795 mL 1.1591 mL 2.8977 mL
25 mM 0.0927 mL 0.4636 mL 0.9273 mL 2.3182 mL
30 mM 0.0773 mL 0.3864 mL 0.7727 mL 1.9318 mL
40 mM 0.0580 mL 0.2898 mL 0.5795 mL 1.4489 mL
50 mM 0.0464 mL 0.2318 mL 0.4636 mL 1.1591 mL
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TTA-P2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TTA-P21072018-68-8T-Type calcium channel inhibitorCalcium ChannelCa2+ channelsCa channelsT-Type calcium channelCNST-type currentscerebellar nuclear neuronsCav3.1 channelsneurology diseaseInhibitorinhibitorinhibit

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