Tuberculosis inhibitor 3

Name: Tuberculosis inhibitor 3
Brand: MedChemExpress
SKU: HY-114147
Rating: 4.5 (1 reviews)

Cat. No.: HY-114147 Purity: 98.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability.

For research use only. We do not sell to patients.

Tuberculosis inhibitor 3 Chemical Structure

CAS No. : 2219325-28-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 230	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 230	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Tuberculosis inhibitor 3 (compound 2i, 50 mg/kg) shows acceptable PK properties with the AUC of 2489 h•ng/mL) is. The T_max of Tuberculosis inhibitor 3 is 0.25 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

524.48

Formula

C₂₁H₂₂F₆N₄O₃S

CAS No.

2219325-28-5

Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCC(CN4CCC(C(F)(F)F)CC4)CC3)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 27.5 mg/mL (52.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9067 mL	9.5333 mL	19.0665 mL
5 mM	0.3813 mL	1.9067 mL	3.8133 mL
10 mM	0.1907 mL	0.9533 mL	1.9067 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.50%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (246 KB) HNMR (237 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Kai Lv, et al. Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. Eur J Med Chem. 2018 May 10;151:1-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9067 mL	9.5333 mL	19.0665 mL	47.6663 mL
	5 mM	0.3813 mL	1.9067 mL	3.8133 mL	9.5333 mL
	10 mM	0.1907 mL	0.9533 mL	1.9067 mL	4.7666 mL
	15 mM	0.1271 mL	0.6356 mL	1.2711 mL	3.1778 mL
	20 mM	0.0953 mL	0.4767 mL	0.9533 mL	2.3833 mL
	25 mM	0.0763 mL	0.3813 mL	0.7627 mL	1.9067 mL
	30 mM	0.0636 mL	0.3178 mL	0.6356 mL	1.5889 mL
	40 mM	0.0477 mL	0.2383 mL	0.4767 mL	1.1917 mL
	50 mM	0.0381 mL	0.1907 mL	0.3813 mL	0.9533 mL