Tubulin polymerization-IN-47

Cat. No.: HY-155962 Purity: 99.51%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC₅₀s of 7 and 12 nM for Chp-134 and Kelly cell line.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-47 Chemical Structure

CAS No. : 2834087-62-4

Size	Price	Stock	Quantity
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 830	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.135 μM Compound: TB-14	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
HCT-116	IC₅₀	0.074 μM Compound: TB-14	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
HepG2	IC₅₀	0.16 μM Compound: TB-14	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
MDA-MB-231	IC₅₀	0.053 μM Compound: TB-14	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]

Molecular Weight

375.42

Formula

C₂₂H₂₁N₃O₃

CAS No.

2834087-62-4

Appearance

Solid

Color

Off-white to gray

SMILES

COC1=CC(C2=NC=CN3C=C(C4=CC=C(C)C=C4)N=C32)=CC(OC)=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (332.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6637 mL	13.3184 mL	26.6368 mL
5 mM	0.5327 mL	2.6637 mL	5.3274 mL
10 mM	0.2664 mL	1.3318 mL	2.6637 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.51%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) HNMR (140 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Joshua Thammathong, et al. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function. ACS Med. Chem. Lett. 2023.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6637 mL	13.3184 mL	26.6368 mL	66.5921 mL
	5 mM	0.5327 mL	2.6637 mL	5.3274 mL	13.3184 mL
	10 mM	0.2664 mL	1.3318 mL	2.6637 mL	6.6592 mL
	15 mM	0.1776 mL	0.8879 mL	1.7758 mL	4.4395 mL
	20 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3296 mL
	25 mM	0.1065 mL	0.5327 mL	1.0655 mL	2.6637 mL
	30 mM	0.0888 mL	0.4439 mL	0.8879 mL	2.2197 mL
	40 mM	0.0666 mL	0.3330 mL	0.6659 mL	1.6648 mL
	50 mM	0.0533 mL	0.2664 mL	0.5327 mL	1.3318 mL
	60 mM	0.0444 mL	0.2220 mL	0.4439 mL	1.1099 mL
	80 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8324 mL
	100 mM	0.0266 mL	0.1332 mL	0.2664 mL	0.6659 mL