2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-62

Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC50 is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC50 of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model.

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Tubulin polymerization-IN-62 Chemical Structure

Tubulin polymerization-IN-62 Chemical Structure

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Tubulin polymerization-IN-62 Related Antibodies

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Description

Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC50 is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC50 of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model[1].

Molecular Weight

608.77

Formula

C37H44N4O4
SMILES

O=C(CC1=NC=C(C2=CC=C(OCCNC(CCCC(NC3[C@@H]4C[C@@H]5C[C@H]3C[C@@H](C5)C4)=O)=O)C=C2)C=C1)NCC6=CC=CC=C6
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Purity & Documentation
References
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Tubulin polymerization-IN-62 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-62Microtubule/TubulinMCF-7A549HCT-1164T1BALB/c mouseInhibitorinhibitorinhibit

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