Tubulin polymerization-IN-62

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Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC₅₀ is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC₅₀ of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model.

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Tubulin polymerization-IN-62 Chemical Structure

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Description	Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC₅₀ is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC₅₀ of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model^[1].
Molecular Weight	608.77
Formula	C₃₇H₄₄N₄O₄
SMILES	O=C(CC1=NC=C(C2=CC=C(OCCNC(CCCC(NC3[C@@H]4C[C@@H]5C[C@H]3C[C@@H](C5)C4)=O)=O)C=C2)C=C1)NCC6=CC=CC=C6
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Wang S, et al., Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation. Eur J Med Chem. 2024 Jun 5;272:116458. [Content Brief]