2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Tyrosinase-IN-16

Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM.

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Tyrosinase-IN-16 Chemical Structure

Tyrosinase-IN-16 Chemical Structure

CAS No. : 126651-85-2

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Tyrosinase-IN-16 Related Antibodies

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Description

Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM[1].

Molecular Weight

256.12

Formula

C8H6BrN3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

S=C1NNC(C2=CC=CC(Br)=C2)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (390.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9044 mL 19.5221 mL 39.0442 mL
5 mM 0.7809 mL 3.9044 mL 7.8088 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9044 mL 19.5221 mL 39.0442 mL 97.6105 mL
5 mM 0.7809 mL 3.9044 mL 7.8088 mL 19.5221 mL
10 mM 0.3904 mL 1.9522 mL 3.9044 mL 9.7610 mL
15 mM 0.2603 mL 1.3015 mL 2.6029 mL 6.5074 mL
20 mM 0.1952 mL 0.9761 mL 1.9522 mL 4.8805 mL
25 mM 0.1562 mL 0.7809 mL 1.5618 mL 3.9044 mL
30 mM 0.1301 mL 0.6507 mL 1.3015 mL 3.2537 mL
40 mM 0.0976 mL 0.4881 mL 0.9761 mL 2.4403 mL
50 mM 0.0781 mL 0.3904 mL 0.7809 mL 1.9522 mL
60 mM 0.0651 mL 0.3254 mL 0.6507 mL 1.6268 mL
80 mM 0.0488 mL 0.2440 mL 0.4881 mL 1.2201 mL
100 mM 0.0390 mL 0.1952 mL 0.3904 mL 0.9761 mL
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Tyrosinase-IN-16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosinase-IN-16126651-85-2TyrosinaseInhibitorinhibitorinhibit

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