Tyrosine kinase-IN-7

Cat. No.: HY-156912 Purity: 99.25%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC₅₀s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC₅₀s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.

For research use only. We do not sell to patients.

Tyrosine kinase-IN-7 Chemical Structure

CAS No. : 345615-74-9

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.630 μM (EGFR^WT), 0.956 μM (EGFR^T790M)^[1]

Molecular Weight

297.37

Formula

C₁₆H₁₅N₃OS

CAS No.

345615-74-9

Appearance

Solid

Color

Off-white to light brown

SMILES

OC1=CC=C(NC2=C3C(CCCC4)=C4SC3=NC=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (336.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3628 mL	16.8141 mL	33.6281 mL
5 mM	0.6726 mL	3.3628 mL	6.7256 mL
10 mM	0.3363 mL	1.6814 mL	3.3628 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (260 KB) HNMR (127 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Elmetwally SA, et al. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorg Chem. 2019 Jul;88:102944. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3628 mL	16.8141 mL	33.6281 mL	84.0704 mL
	5 mM	0.6726 mL	3.3628 mL	6.7256 mL	16.8141 mL
	10 mM	0.3363 mL	1.6814 mL	3.3628 mL	8.4070 mL
	15 mM	0.2242 mL	1.1209 mL	2.2419 mL	5.6047 mL
	20 mM	0.1681 mL	0.8407 mL	1.6814 mL	4.2035 mL
	25 mM	0.1345 mL	0.6726 mL	1.3451 mL	3.3628 mL
	30 mM	0.1121 mL	0.5605 mL	1.1209 mL	2.8023 mL
	40 mM	0.0841 mL	0.4204 mL	0.8407 mL	2.1018 mL
	50 mM	0.0673 mL	0.3363 mL	0.6726 mL	1.6814 mL
	60 mM	0.0560 mL	0.2802 mL	0.5605 mL	1.4012 mL
	80 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0509 mL
	100 mM	0.0336 mL	0.1681 mL	0.3363 mL	0.8407 mL