2. Metabolic Enzyme/Protease
  3. Dopamine β-hydroxylase
  4. U-14624

U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes.

For research use only. We do not sell to patients.

U-14624 Chemical Structure

U-14624 Chemical Structure

CAS No. : 14901-16-7

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1 mg USD 77 In-stock
5 mg USD 155 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2].

In Vivo

U-14624 (50 mg/kg; i.p.; daily for 5-7 days) suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 150-260 g, Male Sprague-Dawley rats[2]
Dosage: 25 mg/kg
Administration: I.p.; daily for 3 days
Result: Prolonged the time required for clearance of pentobarbital from both the plasma and brain, slept significantly longer.
Animal Model: 150-260 g, Male Sprague-Dawley rats[2]
Dosage: 50 mg/kg
Administration: I.p.; daily for 5-7 days
Result: Suppressed the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes.
Molecular Weight

235.33

Formula

C10H9N3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

S=C(NC1=CC=CC=C1)NC2=NC=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (212.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2494 mL 21.2468 mL 42.4935 mL
5 mM 0.8499 mL 4.2494 mL 8.4987 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2494 mL 21.2468 mL 42.4935 mL 106.2338 mL
5 mM 0.8499 mL 4.2494 mL 8.4987 mL 21.2468 mL
10 mM 0.4249 mL 2.1247 mL 4.2494 mL 10.6234 mL
15 mM 0.2833 mL 1.4165 mL 2.8329 mL 7.0823 mL
20 mM 0.2125 mL 1.0623 mL 2.1247 mL 5.3117 mL
25 mM 0.1700 mL 0.8499 mL 1.6997 mL 4.2494 mL
30 mM 0.1416 mL 0.7082 mL 1.4165 mL 3.5411 mL
40 mM 0.1062 mL 0.5312 mL 1.0623 mL 2.6558 mL
50 mM 0.0850 mL 0.4249 mL 0.8499 mL 2.1247 mL
60 mM 0.0708 mL 0.3541 mL 0.7082 mL 1.7706 mL
80 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3279 mL
100 mM 0.0425 mL 0.2125 mL 0.4249 mL 1.0623 mL
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U-14624 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-1462414901-16-7U14624U 14624Dopamine β-hydroxylaseDopamine beta-hydroxylaseDopamine beta-monooxygenaseDopamine β-monooxygenaseN-demethylaseaniline hydroxylasep-nitroanisole O-demethylaseInhibitorinhibitorinhibit

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