2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. U-46619

U-46619  (Synonyms: 9,11-Methanoepoxy PGH2)

Cat. No.: HY-108566 Purity: ≥99.0%
COA Handling Instructions

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U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation.

For research use only. We do not sell to patients.

U-46619 Chemical Structure

U-46619 Chemical Structure

CAS No. : 56985-40-1

Size Price Stock Quantity
Solvent
1 mg (28.5 mM * 100 μL in Methyl acetate) USD 330 In-stock
Solvent
5 mg (28.5 mM * 500 μL in Methyl acetate) USD 990 In-stock
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Based on 5 publication(s) in Google Scholar

U-46619 Related Antibodies

Top Publications Citing Use of Products

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms
DP EP FP IP TXA2/TP TXB2

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Description

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].

IC50 & Target

TXA2/TP

 

In Vitro

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
? U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
? U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
? U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

U-46619 Related Antibodies
In Vivo

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12-15 weeks-old male and female SHR[2]
Dosage: 5 μg/kg
Administration: Intravenous injection
Result: Induceed a significant increase of MABP after 1 min in male SHR.
Molecular Weight

350.49

Formula

C21H34O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (285.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8531 mL 14.2657 mL 28.5315 mL 71.3287 mL
5 mM 0.5706 mL 2.8531 mL 5.7063 mL 14.2657 mL
10 mM 0.2853 mL 1.4266 mL 2.8531 mL 7.1329 mL
15 mM 0.1902 mL 0.9510 mL 1.9021 mL 4.7552 mL
20 mM 0.1427 mL 0.7133 mL 1.4266 mL 3.5664 mL
25 mM 0.1141 mL 0.5706 mL 1.1413 mL 2.8531 mL
30 mM 0.0951 mL 0.4755 mL 0.9510 mL 2.3776 mL
40 mM 0.0713 mL 0.3566 mL 0.7133 mL 1.7832 mL
50 mM 0.0571 mL 0.2853 mL 0.5706 mL 1.4266 mL
60 mM 0.0476 mL 0.2378 mL 0.4755 mL 1.1888 mL
80 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.8916 mL
100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.7133 mL
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U-46619 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-4661956985-40-19,11-Methanoepoxy PGH2U46619U 46619Prostaglandin ReceptorTXA2plateletsshapechangeaggregationrat cerebrovascular endothelial cellsPC-3 cellInhibitorinhibitorinhibit

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