UAMC-3203 hydrochloride

Name: UAMC-3203 hydrochloride
Brand: MedChemExpress
SKU: HY-112909A
Rating: 5.0 (7 reviews)

Cat. No.: HY-112909A Purity: 98.78%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC₅₀ of 12 nM.

For research use only. We do not sell to patients.

UAMC-3203 hydrochloride Chemical Structure

CAS No. : 2271358-65-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 101	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 101	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of UAMC-3203 hydrochloride:

UAMC-3203 Get quote

7 Publications Citing Use of MCE UAMC-3203 hydrochloride

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Biological Activity
Purity & Documentation
References
Customer Review

Description

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC₅₀ of 12 nM^[1].

IC₅₀ & Target

IC50: 12 nM (Ferroptosis)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	IC₅₀	10 nM Compound: 39; UAMC-3203	Inhibition of erastin-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay Inhibition of erastin-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay	[PMID: 30354101]

In Vivo

No toxicity is observed in mice after repeated injections of UAMC-3203 (20 μmol/kg; injected intraperitoneally; daily, over a period of 4 weeks)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild type mice derived from a Gpx4 fl/fl breeding^[1]
Dosage:	20 µmol/kg
Administration:	Injected intraperitoneally; daily, over a period of 4 weeks
Result:	No toxicity was observed.

Molecular Weight

508.12

Formula

C₂₅H₃₈ClN₅O₂S

CAS No.

2271358-65-5

Appearance

Solid

Color

White to off-white

SMILES

O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (98.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9680 mL	9.8402 mL	19.6804 mL
5 mM	0.3936 mL	1.9680 mL	3.9361 mL
10 mM	0.1968 mL	0.9840 mL	1.9680 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.82%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (249 KB) HNMR (219 KB) LCMS (123 KB)

Handling Instructions (2659 KB)

References

[1]. Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9680 mL	9.8402 mL	19.6804 mL	49.2010 mL
	5 mM	0.3936 mL	1.9680 mL	3.9361 mL	9.8402 mL
	10 mM	0.1968 mL	0.9840 mL	1.9680 mL	4.9201 mL
	15 mM	0.1312 mL	0.6560 mL	1.3120 mL	3.2801 mL
	20 mM	0.0984 mL	0.4920 mL	0.9840 mL	2.4600 mL
	25 mM	0.0787 mL	0.3936 mL	0.7872 mL	1.9680 mL
	30 mM	0.0656 mL	0.3280 mL	0.6560 mL	1.6400 mL
	40 mM	0.0492 mL	0.2460 mL	0.4920 mL	1.2300 mL
	50 mM	0.0394 mL	0.1968 mL	0.3936 mL	0.9840 mL
	60 mM	0.0328 mL	0.1640 mL	0.3280 mL	0.8200 mL
	80 mM	0.0246 mL	0.1230 mL	0.2460 mL	0.6150 mL