UBX-382

Cat. No.: HY-160142 Purity: 96.20%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

UBX-382 is an orally available proteolysis-targeting chimeras (PROTACs) that target BTK to inactivate B-cell receptor signaling. UBX-382 shows superior degradation activity for wild-type and mutant BTK proteins and shows anti-cancer activity in murine xenograft models of TMD-8 cells.

For research use only. We do not sell to patients.

UBX-382 Chemical Structure

CAS No. : 2884554-45-2

Size	Price	Stock	Quantity
5 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1990	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Purity & Documentation
References
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Description

Molecular Weight

752.86

Formula

C₄₂H₄₄N₁₀O₄

CAS No.

2884554-45-2

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1C2=CC=C(N3CCC(CC3)CN4CC5=CC(NC6=NC7=C(C(NC8=C(C)C=CC=C8C)=NN7C)C=N6)=CC=C5CC4)C=C2C(N1C9C(NC(CC9)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (132.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3283 mL	6.6413 mL	13.2827 mL
5 mM	0.2657 mL	1.3283 mL	2.6565 mL
10 mM	0.1328 mL	0.6641 mL	1.3283 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.20%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (246 KB) HNMR (294 KB) RP-HPLC (257 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Lim YS, et al. Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models. Blood Adv. 2023;7(1):92-105. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3283 mL	6.6413 mL	13.2827 mL	33.2067 mL
	5 mM	0.2657 mL	1.3283 mL	2.6565 mL	6.6413 mL
	10 mM	0.1328 mL	0.6641 mL	1.3283 mL	3.3207 mL
	15 mM	0.0886 mL	0.4428 mL	0.8855 mL	2.2138 mL
	20 mM	0.0664 mL	0.3321 mL	0.6641 mL	1.6603 mL
	25 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.3283 mL
	30 mM	0.0443 mL	0.2214 mL	0.4428 mL	1.1069 mL
	40 mM	0.0332 mL	0.1660 mL	0.3321 mL	0.8302 mL
	50 mM	0.0266 mL	0.1328 mL	0.2657 mL	0.6641 mL
	60 mM	0.0221 mL	0.1107 mL	0.2214 mL	0.5534 mL
	80 mM	0.0166 mL	0.0830 mL	0.1660 mL	0.4151 mL
	100 mM	0.0133 mL	0.0664 mL	0.1328 mL	0.3321 mL

UBX-382 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UBX-3822884554-45-2UBX382UBX 382BtkBruton tyrosine kinaseB-cell lymphomasTMD-8in murine xenograft models of TMD-8 cellsB-cell receptorInhibitorinhibitorinhibit

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