UDM-001651

Cat. No.: HY-128345: FAQs
Data Sheet Handling Instructions

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UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC₅₀=4 nM; K_d=1.4 nM). UDM-001651 shows antiplatelet potency (IC₅₀=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP).

For research use only. We do not sell to patients.

UDM-001651 Chemical Structure

CAS No. : 1477497-01-0

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PAR1 PAR2 PAR4

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PAR4

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	2.4 nM Compound: 54; UDM-001651	Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization preincubated for 30 mins followed by AYPGKF addition and measured by calcium indicator-based FLIPR assay Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization preincubated for 30 mins followed by AYPGKF addition and measured by calcium indicator-based FLIPR assay	[PMID: 31246024]
Platelet	IC₅₀	25 nM Compound: 1; UDM-00165	Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay	[PMID: 35729784]

Molecular Weight

513.56

Formula

C₂₈H₂₃N₃O₅S

CAS No.

1477497-01-0

SMILES

COC1=CC(OCC2=CC=CC(OCC3=CC=CC=C3)=C2)=C4C=C(C5=CN6C(SC(OC)=N6)=N5)OC4=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27. [Content Brief]

UDM-001651 Related Classifications

Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDM-0016511477497-01-0UDM001651UDM 001651Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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