UDP-GlcNAc disodium (Synonyms: UDP-α-D-N-Acetylglucosamine disodium)

Name: UDP-GlcNAc disodium
Brand: MedChemExpress
SKU: HY-112174
Rating: 5.0 (4 reviews)

Cat. No.: HY-112174 Purity: 98.60%: FAQs
Data Sheet SDS COA Handling Instructions

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UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

For research use only. We do not sell to patients.

UDP-GlcNAc disodium Chemical Structure

CAS No. : 91183-98-1

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 136	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
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Based on 4 publication(s) in Google Scholar

Other Forms of UDP-GlcNAc disodium:

UDP-GlcNAc-¹³C disodium Get quote

4 Publications Citing Use of MCE UDP-GlcNAc disodium

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Description

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

In Vitro

OGT is a nucleocytoplasmic glycosyltransferase (uridine diphospho-N--acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase or O-GlcNAc transferase) assigned to the GT41 family in the CAZY (Carbohydrate-Active enZYme) database. Using UDP-GlcNAc Disodium Salt (UDP-GlcNAc) as the donor substrate, this enzyme modifies thousands of proteins by adding a unique N-acetylglucosamine residue onto acceptor substrates mainly confined within cytosol and nucleus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

651.32

Formula

C₁₇H₂₅N₃Na₂O₁₇P₂

CAS No.

91183-98-1

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](N2C(NC(C=C2)=O)=O)O[C@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@H](O)[C@@H](CO)O3)O)NC(C)=O)(O[Na])=O)(O[Na])=O)[C@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (383.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 125 mg/mL (191.92 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5353 mL	7.6767 mL	15.3534 mL
5 mM	0.3071 mL	1.5353 mL	3.0707 mL
10 mM	0.1535 mL	0.7677 mL	1.5353 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Lefebvre T, et al. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol Biol. 2013;1022:147-59. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.5353 mL	7.6767 mL	15.3534 mL	38.3836 mL
	5 mM	0.3071 mL	1.5353 mL	3.0707 mL	7.6767 mL
	10 mM	0.1535 mL	0.7677 mL	1.5353 mL	3.8384 mL
	15 mM	0.1024 mL	0.5118 mL	1.0236 mL	2.5589 mL
	20 mM	0.0768 mL	0.3838 mL	0.7677 mL	1.9192 mL
	25 mM	0.0614 mL	0.3071 mL	0.6141 mL	1.5353 mL
	30 mM	0.0512 mL	0.2559 mL	0.5118 mL	1.2795 mL
	40 mM	0.0384 mL	0.1919 mL	0.3838 mL	0.9596 mL
	50 mM	0.0307 mL	0.1535 mL	0.3071 mL	0.7677 mL
	60 mM	0.0256 mL	0.1279 mL	0.2559 mL	0.6397 mL
	80 mM	0.0192 mL	0.0960 mL	0.1919 mL	0.4798 mL
	100 mM	0.0154 mL	0.0768 mL	0.1535 mL	0.3838 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

UDP-GlcNAc disodium Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDP-GlcNAc disodium91183-98-1UDP-α-D-N-Acetylglucosamine disodiumOGTO-linked N-acetylglucosaminyltransferaseO-GlcNAc transferaseInhibitorinhibitorinhibit

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UDP-GlcNAc disodium (Synonyms: UDP-α-D-N-Acetylglucosamine disodium)

Customer Review

Other Forms of UDP-GlcNAc disodium:

UDP-GlcNAc disodium Related Antibodies

4 Publications Citing Use of MCE UDP-GlcNAc disodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

UDP-GlcNAc disodium Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

UDP-GlcNAc disodium Related Classifications

Keywords:

Your Recently Viewed Products:

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