2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. UniPR1331

UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish.

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UniPR1331 Chemical Structure

UniPR1331 Chemical Structure

CAS No. : 1809170-59-9

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Based on 1 publication(s) in Google Scholar

UniPR1331 Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish[1].

Molecular Weight

560.77

Formula

C35H48N2O4
CAS No.
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N[C@H](C(O)=O)CC3=CNC4=CC=CC=C34)=O)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6(C(C[C@H](CC6)O)=CC5)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (44.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7833 mL 8.9163 mL 17.8326 mL
5 mM 0.3567 mL 1.7833 mL 3.5665 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7833 mL 8.9163 mL 17.8326 mL 44.5816 mL
5 mM 0.3567 mL 1.7833 mL 3.5665 mL 8.9163 mL
10 mM 0.1783 mL 0.8916 mL 1.7833 mL 4.4582 mL
15 mM 0.1189 mL 0.5944 mL 1.1888 mL 2.9721 mL
20 mM 0.0892 mL 0.4458 mL 0.8916 mL 2.2291 mL
25 mM 0.0713 mL 0.3567 mL 0.7133 mL 1.7833 mL
30 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4861 mL
40 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1145 mL
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UniPR1331 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UniPR13311809170-59-9UniPR 1331UniPR-1331VEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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