2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. UniPR1331

UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish.

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UniPR1331 Chemical Structure

UniPR1331 Chemical Structure

CAS No. : 1809170-59-9

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Based on 1 publication(s) in Google Scholar

UniPR1331 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish[1].

Molecular Weight

560.77

Formula

C35H48N2O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N[C@H](C(O)=O)CC3=CNC4=CC=CC=C34)=O)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6(C(C[C@H](CC6)O)=CC5)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (44.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7833 mL 8.9163 mL 17.8326 mL
5 mM 0.3567 mL 1.7833 mL 3.5665 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7833 mL 8.9163 mL 17.8326 mL 44.5816 mL
5 mM 0.3567 mL 1.7833 mL 3.5665 mL 8.9163 mL
10 mM 0.1783 mL 0.8916 mL 1.7833 mL 4.4582 mL
15 mM 0.1189 mL 0.5944 mL 1.1888 mL 2.9721 mL
20 mM 0.0892 mL 0.4458 mL 0.8916 mL 2.2291 mL
25 mM 0.0713 mL 0.3567 mL 0.7133 mL 1.7833 mL
30 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4861 mL
40 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1145 mL
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UniPR1331 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UniPR13311809170-59-9UniPR 1331UniPR-1331VEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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