2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Urea-d4

Urea-d4  (Synonyms: 1,1,3,3-Tetradeuteriourea)

Cat. No.: HY-Y0271S1 Purity: 99.95%
COA Handling Instructions

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Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

For research use only. We do not sell to patients.

Urea-d<sub>4</sub> Chemical Structure

Urea-d4 Chemical Structure

CAS No. : 1433-11-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Urea-d4:

Urea-d4 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urea-d4 Related Antibodies
Molecular Weight

64.08

Formula

CD4N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[2H]N([2H])C(N([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (1560.55 mM; Need ultrasonic)

H2O : 100 mg/mL (1560.55 mM; Need ultrasonic)

DMSO : 100 mg/mL (1560.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 15.6055 mL 78.0275 mL 156.0549 mL
5 mM 3.1211 mL 15.6055 mL 31.2110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO 1 mM 15.6055 mL 78.0275 mL 156.0549 mL 390.1373 mL
5 mM 3.1211 mL 15.6055 mL 31.2110 mL 78.0275 mL
10 mM 1.5605 mL 7.8027 mL 15.6055 mL 39.0137 mL
15 mM 1.0404 mL 5.2018 mL 10.4037 mL 26.0092 mL
20 mM 0.7803 mL 3.9014 mL 7.8027 mL 19.5069 mL
25 mM 0.6242 mL 3.1211 mL 6.2422 mL 15.6055 mL
30 mM 0.5202 mL 2.6009 mL 5.2018 mL 13.0046 mL
40 mM 0.3901 mL 1.9507 mL 3.9014 mL 9.7534 mL
50 mM 0.3121 mL 1.5605 mL 3.1211 mL 7.8027 mL
60 mM 0.2601 mL 1.3005 mL 2.6009 mL 6.5023 mL
80 mM 0.1951 mL 0.9753 mL 1.9507 mL 4.8767 mL
100 mM 0.1561 mL 0.7803 mL 1.5605 mL 3.9014 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Urea-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urea-d41433-11-01,1,3,3-TetradeuterioureaEndogenous MetaboliteInhibitorinhibitorinhibit

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