Ursodeoxycholic acid-2,2,4,4-d₄

Name: Ursodeoxycholic acid-2,2,4,4-d 4
Brand: MedChemExpress
SKU: HY-113478S
Rating: 4.5 (1 reviews)

Cat. No.: HY-113478S Purity: 99.52%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ursodeoxycholic acid-2,2,4,4-d₄ is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection[1][2][3][4][5].

For research use only. We do not sell to patients.

Ursodeoxycholic acid-2,2,4,4-d<sub>4</sub> Chemical Structure

Ursodeoxycholic acid-2,2,4,4-d₄ Chemical Structure

CAS No. : 347841-46-7

Size	Price	Stock	Quantity
500 μg	USD 75	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ursodeoxycholic acid-2,2,4,4-d₄:

3β-Ursodeoxycholic acid Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.60

Formula

C₂₄H₃₆D₄O₄

CAS No.

347841-46-7

Unlabeled CAS

128-13-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C([C@H](O)C(C4)([2H])[2H])([2H])[2H])[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMF : ≥ 10 mg/mL (25.21 mM)

DMSO : ≥ 10 mg/mL (25.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 10 mg/mL (25.21 mM)

Ethanol : ≥ 1 mg/mL (2.52 mM)

DMSO:PBS(pH 7.2) (1:4) : ≥ 0.2 mg/mL (0.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5214 mL	12.6072 mL	25.2143 mL
5 mM	0.5043 mL	2.5214 mL	5.0429 mL
10 mM	0.2521 mL	1.2607 mL	2.5214 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.52%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (252 KB) HNMR (317 KB) RP-HPLC (344 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Jackson H, et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7. [Content Brief]

[3]. Kumar D, et al. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001 Jan;16(1):3-14. [Content Brief]

[4]. Biao Nie, et al. Specific Bile Acids Inhibit Hepatic Fatty Acid Uptake in Mice. Hepatology. 2012 Oct;56(4):1300-10. [Content Brief]

[5]. Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / Ethanol / DMF / DMSO / DMF	1 mM	2.5214 mL	12.6072 mL	25.2143 mL	63.0358 mL
DMF / DMSO / DMF	5 mM	0.5043 mL	2.5214 mL	5.0429 mL	12.6072 mL
	10 mM	0.2521 mL	1.2607 mL	2.5214 mL	6.3036 mL
	15 mM	0.1681 mL	0.8405 mL	1.6810 mL	4.2024 mL
	20 mM	0.1261 mL	0.6304 mL	1.2607 mL	3.1518 mL
	25 mM	0.1009 mL	0.5043 mL	1.0086 mL	2.5214 mL