Ursodeoxycholic acid sodium (Synonyms: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium)

Name: Ursodeoxycholic acid sodium
Brand: MedChemExpress
SKU: HY-13771A
Rating: 5.0 (12 reviews)

Cat. No.: HY-13771A Purity: 99.06%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active.

For research use only. We do not sell to patients.

Ursodeoxycholic acid sodium Chemical Structure

CAS No. : 2898-95-5

Size	Price	Stock	Quantity
50 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
1 g	USD 180	In-stock	Estimated Time of Arrival: December 31
5 g	USD 630	In-stock	Estimated Time of Arrival: December 31
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Based on 12 publication(s) in Google Scholar

Other Forms of Ursodeoxycholic acid sodium:

Ursodeoxycholic acid In-stock

12 Publications Citing Use of MCE Ursodeoxycholic acid sodium

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Biological Activity
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Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vivo

Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) sodium results in weight loss in C57BL/6J wildtype mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5 week old C57BL/6J WT mice (male and female)^[1]
Dosage:	50, 150, and 450 mg/kg dissolved in corn oil
Administration:	Oral gavage; daily for 21 days
Result:	Mice in the 50 and 450 mg/kg groups sustained significant weight loss within a week. At 50 mg/kg, this weight loss persisted over the course of the experiment. At 450 mg/kg, initially weight loss was noted during the first and third week of ursodiol administration. At 150 mg/kg, it did not have significantly different weights compared to the untreated mice.

Molecular Weight

414.55

Formula

C₂₄H₃₉NaO₄

CAS No.

2898-95-5

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@@H]3O)C

Structure Classification

Steroids

Initial Source

Microorganisms

intestinal bacteria

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (301.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (241.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4123 mL	12.0613 mL	24.1225 mL
5 mM	0.4825 mL	2.4123 mL	4.8245 mL
10 mM	0.2412 mL	1.2061 mL	2.4123 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline
Solubility: 50 mg/mL (120.61 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.06%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (250 KB) HNMR (275 KB) RP-HPLC (210 KB)

Handling Instructions (2659 KB)

References

[1]. Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021;16(2):e0246161. Published 2021 Feb 18. [Content Brief]

[2]. Goossens JF, et al. Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy. Pharmacol Ther. 2019;203:107396. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.4123 mL	12.0613 mL	24.1225 mL	60.3064 mL
	5 mM	0.4825 mL	2.4123 mL	4.8245 mL	12.0613 mL
	10 mM	0.2412 mL	1.2061 mL	2.4123 mL	6.0306 mL
	15 mM	0.1608 mL	0.8041 mL	1.6082 mL	4.0204 mL
	20 mM	0.1206 mL	0.6031 mL	1.2061 mL	3.0153 mL
	25 mM	0.0965 mL	0.4825 mL	0.9649 mL	2.4123 mL
	30 mM	0.0804 mL	0.4020 mL	0.8041 mL	2.0102 mL
	40 mM	0.0603 mL	0.3015 mL	0.6031 mL	1.5077 mL
	50 mM	0.0482 mL	0.2412 mL	0.4825 mL	1.2061 mL
	60 mM	0.0402 mL	0.2010 mL	0.4020 mL	1.0051 mL
	80 mM	0.0302 mL	0.1508 mL	0.3015 mL	0.7538 mL
	100 mM	0.0241 mL	0.1206 mL	0.2412 mL	0.6031 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Ursodeoxycholic acid sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ursodeoxycholic acid sodium (Synonyms: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium)

Customer Review

Other Forms of Ursodeoxycholic acid sodium:

Ursodeoxycholic acid sodium Related Antibodies

12 Publications Citing Use of MCE Ursodeoxycholic acid sodium

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ursodeoxycholic acid sodium Related Classifications

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