Val-Cit-PAB-Exatecan TFA (Synonyms: Val-Cit-PAB-DX8951 TFA)

Cat. No.: HY-153031A Purity: 98.14%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) TFA is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan TFA is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker.

For research use only. We do not sell to patients.

Val-Cit-PAB-Exatecan TFA Chemical Structure

CAS No. : 2928571-44-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Val-Cit-PAB-Exatecan TFA:

Val-Cit-PAB-Exatecan Get quote

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

954.92

Formula

C₄₅H₅₀F₄N₈O₁₁

CAS No.

2928571-44-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (209.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0472 mL	5.2360 mL	10.4721 mL
5 mM	0.2094 mL	1.0472 mL	2.0944 mL
10 mM	0.1047 mL	0.5236 mL	1.0472 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.14%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (263 KB) HNMR (180 KB) RP-HPLC (240 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0472 mL	5.2360 mL	10.4721 mL	26.1802 mL
	5 mM	0.2094 mL	1.0472 mL	2.0944 mL	5.2360 mL
	10 mM	0.1047 mL	0.5236 mL	1.0472 mL	2.6180 mL
	15 mM	0.0698 mL	0.3491 mL	0.6981 mL	1.7453 mL
	20 mM	0.0524 mL	0.2618 mL	0.5236 mL	1.3090 mL
	25 mM	0.0419 mL	0.2094 mL	0.4189 mL	1.0472 mL
	30 mM	0.0349 mL	0.1745 mL	0.3491 mL	0.8727 mL
	40 mM	0.0262 mL	0.1309 mL	0.2618 mL	0.6545 mL
	50 mM	0.0209 mL	0.1047 mL	0.2094 mL	0.5236 mL
	60 mM	0.0175 mL	0.0873 mL	0.1745 mL	0.4363 mL
	80 mM	0.0131 mL	0.0655 mL	0.1309 mL	0.3273 mL
	100 mM	0.0105 mL	0.0524 mL	0.1047 mL	0.2618 mL

Val-Cit-PAB-Exatecan TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Val-Cit-PAB-Exatecan2928571-44-0Val-Cit-PAB-DX8951Drug-Linker Conjugates for ADCTopoisomeraseInhibitorinhibitorinhibit

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