2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. Val-Cit-PABC-DOX

Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC.

For research use only. We do not sell to patients.

Val-Cit-PABC-DOX Chemical Structure

Val-Cit-PABC-DOX Chemical Structure

CAS No. : 1022094-34-3

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Val-Cit-PABC-DOX Related Antibodies

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Topoisomerase Topo I Topo II

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Description

Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC[1].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

Molecular Weight

948.97

Formula

C46H56N6O16
CAS No.
SMILES

OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC6=CC=C(C=C6)NC([C@H](CCCNC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Val-Cit-PABC-DOX Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Val-Cit-PABC-DOX1022094-34-3Drug-Linker Conjugates for ADCTopoisomeraseepsilon-poly-L-lysinedrug conjugateDNA topoisomerase Itopoisomerase IIInhibitorinhibitorinhibit

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