2. Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection Neuronal Signaling Stem Cell/Wnt Metabolic Enzyme/Protease
  3. HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite
  4. Valproic acid-d15

Valproic acid-d15  (Synonyms: VPA-d15; 2-Propylpentanoic Acid-d15)

Cat. No.: HY-10585S2 Purity: ≥99.0%
COA Handling Instructions

Molarity Calculator

Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

For research use only. We do not sell to patients.

Valproic acid-d<sub>15</sub> Chemical Structure

Valproic acid-d15 Chemical Structure

CAS No. : 362049-65-8

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5 mg USD 65 In-stock
10 mg USD 108 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Valproic acid-d15:

Valproic acid-d15 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Valproic acid-d15 Related Antibodies
Molecular Weight

159.30

Formula

C8HD15O2
CAS No.
Unlabeled CAS

99-66-1
Appearance

Liquid (Density: 0.91 g/cm3)

Color

Colorless to light yellow

SMILES

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O)=O)([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (627.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (627.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2775 mL 31.3873 mL 62.7746 mL
5 mM 1.2555 mL 6.2775 mL 12.5549 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 6.2775 mL 31.3873 mL 62.7746 mL 156.9366 mL
5 mM 1.2555 mL 6.2775 mL 12.5549 mL 31.3873 mL
10 mM 0.6277 mL 3.1387 mL 6.2775 mL 15.6937 mL
15 mM 0.4185 mL 2.0925 mL 4.1850 mL 10.4624 mL
20 mM 0.3139 mL 1.5694 mL 3.1387 mL 7.8468 mL
25 mM 0.2511 mL 1.2555 mL 2.5110 mL 6.2775 mL
30 mM 0.2092 mL 1.0462 mL 2.0925 mL 5.2312 mL
40 mM 0.1569 mL 0.7847 mL 1.5694 mL 3.9234 mL
50 mM 0.1255 mL 0.6277 mL 1.2555 mL 3.1387 mL
60 mM 0.1046 mL 0.5231 mL 1.0462 mL 2.6156 mL
80 mM 0.0785 mL 0.3923 mL 0.7847 mL 1.9617 mL
100 mM 0.0628 mL 0.3139 mL 0.6277 mL 1.5694 mL
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Valproic acid-d15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valproic acid-d15362049-65-8VPA-d152-Propylpentanoic Acid-d15HDACAutophagyMitophagyHIVNotchEndogenous MetaboliteHistone deacetylasesMitochondrial AutophagyHuman immunodeficiency virusInhibitorinhibitorinhibit

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