1. Cell Cycle/DNA Damage
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  3. VCP Activator 1

VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail.

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VCP Activator 1 Chemical Structure

VCP Activator 1 Chemical Structure

Size Price Stock Quantity
1 mg USD 208 In-stock
5 mg USD 520 In-stock
10 mg USD 840 In-stock
25 mg USD 1680 In-stock
50 mg USD 2700 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail[1].

Molecular Weight

354.47

Formula

C20H22N2O2S

Appearance

Solid

Color

White to off-white

SMILES

CCSC1=CC=CC=C1NC(C[C@@H](C)N2CC3=C(C=CC=C3)C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (846.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8211 mL 14.1056 mL 28.2111 mL
5 mM 0.5642 mL 2.8211 mL 5.6422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8211 mL 14.1056 mL 28.2111 mL 70.5278 mL
5 mM 0.5642 mL 2.8211 mL 5.6422 mL 14.1056 mL
10 mM 0.2821 mL 1.4106 mL 2.8211 mL 7.0528 mL
15 mM 0.1881 mL 0.9404 mL 1.8807 mL 4.7019 mL
20 mM 0.1411 mL 0.7053 mL 1.4106 mL 3.5264 mL
25 mM 0.1128 mL 0.5642 mL 1.1284 mL 2.8211 mL
30 mM 0.0940 mL 0.4702 mL 0.9404 mL 2.3509 mL
40 mM 0.0705 mL 0.3526 mL 0.7053 mL 1.7632 mL
50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.4106 mL
60 mM 0.0470 mL 0.2351 mL 0.4702 mL 1.1755 mL
80 mM 0.0353 mL 0.1763 mL 0.3526 mL 0.8816 mL
100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL
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VCP Activator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
VCP Activator 1
Cat. No.:
HY-157508
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