VCP Activator 1

Cat. No.: HY-157508 Purity: 99.71%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail.

For research use only. We do not sell to patients.

VCP Activator 1 Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 840	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1680	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2700	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Description

Molecular Weight

354.47

Formula

C₂₀H₂₂N₂O₂S

Appearance

Solid

Color

White to off-white

SMILES

CCSC1=CC=CC=C1NC(C[C@@H](C)N2CC3=C(C=CC=C3)C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 300 mg/mL (846.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8211 mL	14.1056 mL	28.2111 mL
5 mM	0.5642 mL	2.8211 mL	5.6422 mL
10 mM	0.2821 mL	1.4106 mL	2.8211 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.71%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (242 KB) RP-HPLC (264 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Jones NH, et al. Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry. bioRxiv [Preprint]. 2023 Oct 2:2023.10.02.560478. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8211 mL	14.1056 mL	28.2111 mL	70.5278 mL
	5 mM	0.5642 mL	2.8211 mL	5.6422 mL	14.1056 mL
	10 mM	0.2821 mL	1.4106 mL	2.8211 mL	7.0528 mL
	15 mM	0.1881 mL	0.9404 mL	1.8807 mL	4.7019 mL
	20 mM	0.1411 mL	0.7053 mL	1.4106 mL	3.5264 mL
	25 mM	0.1128 mL	0.5642 mL	1.1284 mL	2.8211 mL
	30 mM	0.0940 mL	0.4702 mL	0.9404 mL	2.3509 mL
	40 mM	0.0705 mL	0.3526 mL	0.7053 mL	1.7632 mL
	50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4106 mL
	60 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1755 mL
	80 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8816 mL
	100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.7053 mL

VCP Activator 1 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VCP Activator 1VCP Activator1VCP Activator-1p97VCPCdc48ATPallosteric pocketbinding sitephenylalanine residueInhibitorinhibitorinhibit

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