2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Verlukast

Verlukast  (Synonyms: MK-679; L 668019)

Cat. No.: HY-76511 Purity: 98.61% ee.: 99.42%
SDS COA Handling Instructions

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Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma.

For research use only. We do not sell to patients.

Verlukast Chemical Structure

Verlukast Chemical Structure

CAS No. : 120443-16-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Verlukast:

Verlukast Related Antibodies

Top Publications Citing Use of Products

View All Leukotriene Receptor Isoform Specific Products:

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma[1].

IC50 & Target

leukotriene receptor[1]
Cellular Effect
Cell Line Type Value Description References
MDCK IC50
2.8 μM
Compound: 4, MK-571
Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay
Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay
[PMID: 22112208]
Molecular Weight

515.09

Formula

C26H27ClN2O3S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CCS[C@@]([H])(C1=CC(/C=C/C2=NC3=CC(Cl)=CC=C3C=C2)=CC=C1)SCCC(O)=O)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5.15 mg/mL (10.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9414 mL 9.7071 mL 19.4142 mL
5 mM 0.3883 mL 1.9414 mL 3.8828 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.61% ee.: 99.42%

SDS (252 KB)

COA (248 KB) HNMR (474 KB) NP-HPLC (205 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9414 mL 9.7071 mL 19.4142 mL 48.5355 mL
5 mM 0.3883 mL 1.9414 mL 3.8828 mL 9.7071 mL
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Verlukast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verlukast120443-16-5MK-679 L 668019MK679MK 679L668019L 668019L-668019Leukotriene ReceptororalasthmaleukotrieneInhibitorinhibitorinhibit

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