2. Anti-infection Apoptosis
  3. Bacterial Apoptosis
  4. Vitexilactone

Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer.

For research use only. We do not sell to patients.

Vitexilactone Chemical Structure

Vitexilactone Chemical Structure

CAS No. : 61263-49-8

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Based on 1 publication(s) in Google Scholar

Vitexilactone Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 GI50
> 5000 ng/mL
Compound: 13
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
HL-60 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23327905]
PC-12 GI50
> 5000 ng/mL
Compound: 13
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
RAW264.7 IC50
42.5 μM
Compound: 1
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 24035341]
ZR-75-30 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
[PMID: 23327905]
In Vitro

Vitexilactone shows significant antimicrobial activity towards E. coli with an MIC value ＞90 μg/mL[1].
Vitexilactone (0-100 μg/mL; 17-24 h) inhibits cell proliferation of mammalian cancer cells[2].
Vitexilactone (25-100 μg/mL; 17 h) induces cell apoptosis at higher concentrations, while inhibits the cell cycle G0/G1 phase at lower concentrations of tsFT210 and K562 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vitexilactone Related Antibodies

Cell Proliferation Assay[2]

Cell Line: tsFT210 and K562 cells lines
Concentration: 0-100 μg/mL
Incubation Time: 17-24 hours
Result: Inhibited cell proliferation of mammalian cancer cells with IC50 values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively.

Apoptosis Analysis[2]

Cell Line: tsFT210 and K562 cell lines
Concentration: 25-100 μg/mL
Incubation Time: 17 hours
Result: Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL.

Cell Cycle Analysis[2]

Cell Line: tsFT210 and K562 cell lines
Concentration: 25-100 μg/mL
Incubation Time: 17 hours
Result: Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.
Molecular Weight

378.50

Formula

C22H34O5
CAS No.
SMILES

O=C1OCC(CC[C@@]2(O)[C@H](C)C[C@@H](OC(C)=O)[C@@]3([H])C(C)(C)CCC[C@]23C)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Vitexilactone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vitexilactone61263-49-8BacterialApoptosisditerpenoidnatural productantimicrobialapoptosiscell cyclecancertsFT210K562Inhibitorinhibitorinhibit

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