Volanesorsen sodium (Synonyms: ISIS 304801 sodium)

Cat. No.: HY-145727A Purity: 94.25%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Volanesorsen sodium is an antisense oligonucleotide thay targes Apolipoprotein C-III (APOC3) mRNA. Volanesorsen sodium is used for the study of familial chylomicronemia syndrome.

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), sodium salt

Volanesorsen sodium Chemical Structure

CAS No. : 1573402-50-2

Size	Price	Stock	Quantity
1 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 598	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 941	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Volanesorsen sodium:

Volanesorsen Get quote
Volanesorsen triethylamine Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Apolipoprotein Isoform Specific Products:

View All Isoforms

apoE apoB apoC3

Biological Activity
Purity & Documentation
References
Customer Review

Description

Volanesorsen sodium is an antisense oligonucleotide thay targes Apolipoprotein C-III (APOC3) mRNA. Volanesorsen sodium is used for the study of familial chylomicronemia syndrome.

IC₅₀ & Target

apoC3

Molecular Weight

7583.00

Formula

C₂₃₀H₃₀₁N₆₃Na₁₉O₁₂₅P₁₉S₁₉

CAS No.

1573402-50-2

Appearance

Solid

Color

White to off-white

SMILES

[Volanesorsen (sodium)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 94.25%

Select Batch:

Data Sheet (265 KB) SDS (252 KB)

COA (245 KB) RP-HPLC (706 KB)

Handling Instructions (2659 KB)

References

[1]. Graham MJ, Lee RG, Bell TA 3rd, et al. Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans. Circ Res. 2013;112(11):1479-1490. [Content Brief]

[2]. Gaudet D, Brisson D, Tremblay K, et al. Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014;371(23):2200-2206. [Content Brief]

[3]. Post N, Yu R, Greenlee S, et al. Metabolism and Disposition of Volanesorsen, a 2'-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species. Drug Metab Dispos. 2019;47(10):1164-1173. [Content Brief]

Volanesorsen sodium Related Classifications

Endocrinology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Volanesorsen1573402-50-2ISIS 304801ISIS304801ISIS-304801ApolipoproteinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Volanesorsen sodium (Synonyms: ISIS 304801 sodium)

Customer Review

Other Forms of Volanesorsen sodium:

Volanesorsen sodium Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Apolipoprotein Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Volanesorsen sodium Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report