2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Volanesorsen

Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes.

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU)

Volanesorsen Chemical Structure

CAS No. : 915430-78-3

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5 mg USD 598 In-stock
10 mg USD 941 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Volanesorsen:

Volanesorsen Related Antibodies

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apoE apoB apoC3

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Description

Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes[1][2][3][4][5].

IC50 & Target

apoC3

 

In Vivo

Volanesorsen (1.5-50 mg/kg; i.p.; once a week for 2 weeks) dose-dependently reduces human apolipoprotein CIII (apo-CIII) mRNA, plasma apo-CIII protein and triglyceride (TG) levels in human apo-CIII transgenic mice[1].
Volanesorsen (4-40 mg/kg; s.c.; once a week for 13 weeks) dose-responsively reduces apoC-III mRNA levels in the liver of cynomolgus monkeys[1].
Volanesorsen (10 mg/kg; s.c.; once weekly for 10 weeks) reduces plasma triglyceride levels in hypertriglyceridemic rhesus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chow-Fed Cynomolgus[1]
Dosage: 4, 8, 12 and 40 mg/kg
Administration: Subcutaneous injection (s.c.) Once a week for 13 weeks
Result: Reduced apoC-III mRNA by 47%, 51%, 80%, and 89% in a dose-responsive manner.
Animal Model: Rhesus monkeys with hypertriglyceridemia after taking high fructose supplements[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection (s.c.) Once a week for 10 weeks
Result: Reduced plasma triglycerides, very low–density lipoprotein (VLDL)+chylomicron triglyceride, and decreased postprandial triglyceride excursion, while increasing high-density lipoprotein-cholesterol (HDL-C) in hypertriglyceridemic rhesus monkeys.
Clinical Trial
Molecular Weight

7165.00

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU)
SMILES

[Volanesorsen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (6.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1396 mL 0.6978 mL 1.3957 mL
5 mM 0.0279 mL 0.1396 mL 0.2791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1396 mL 0.6978 mL 1.3957 mL 3.4892 mL
5 mM 0.0279 mL 0.1396 mL 0.2791 mL 0.6978 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Volanesorsen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Volanesorsen915430-78-3ISIS 304801ISIS304801ISIS-304801ApolipoproteinInhibitorinhibitorinhibit

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