2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU-1545

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.

For research use only. We do not sell to patients.

VU-1545 Chemical Structure

VU-1545 Chemical Structure

CAS No. : 890764-63-3

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5 mg USD 170 In-stock
10 mg USD 270 In-stock
25 mg USD 520 In-stock
50 mg USD 820 In-stock
100 mg USD 1150 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

VU-1545 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM[1].

IC50 & Target[1]

mGluR5

156 nM (Ki)

mGluR5

9.6 nM (EC50)

In Vitro

VU-1545 (10 and 100 μM) promotes AKT activation. VU-1545 at the concentrations of 0.1 and 1.0 μM efficiently promots Akt activation above basal levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU-1545 Related Antibodies

Western Blot Analysis[2]

Cell Line: Neuronal cells
Concentration: 10 and 100 μM
Incubation Time: 5 minutes
Result: Promoted Akt phosphorylation as efficiently at the concentration of 10.0 μM as at the concentration of 100.0 μM.
Molecular Weight

402.38

Formula

C22H15FN4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3F)C4=CC=C([N+]([O-])=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4852 mL 12.4261 mL 24.8521 mL
5 mM 0.4970 mL 2.4852 mL 4.9704 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4852 mL 12.4261 mL 24.8521 mL 62.1303 mL
5 mM 0.4970 mL 2.4852 mL 4.9704 mL 12.4261 mL
10 mM 0.2485 mL 1.2426 mL 2.4852 mL 6.2130 mL
15 mM 0.1657 mL 0.8284 mL 1.6568 mL 4.1420 mL
20 mM 0.1243 mL 0.6213 mL 1.2426 mL 3.1065 mL
25 mM 0.0994 mL 0.4970 mL 0.9941 mL 2.4852 mL
30 mM 0.0828 mL 0.4142 mL 0.8284 mL 2.0710 mL
40 mM 0.0621 mL 0.3107 mL 0.6213 mL 1.5533 mL
50 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2426 mL
60 mM 0.0414 mL 0.2071 mL 0.4142 mL 1.0355 mL
80 mM 0.0311 mL 0.1553 mL 0.3107 mL 0.7766 mL
100 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.6213 mL
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VU-1545 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU-1545890764-63-3VU1545VU 1545mGluRMetabotropic glutamate receptorsmGluR5PAMInhibitorinhibitorinhibit

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