2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH Epoxide Hydrolase
  4. VU534

VU534 is a NAPE-PLD activator, with an EC50 of 0.30 μM. VU534 is dual inhibitors of FAAH and sEH (IC50 of 1.2 μM). VU534 increases efferocytosis in a NAPE-PLD dependent manner. VU534 has the potential for cardiometabolic diseases study [1] .

For research use only. We do not sell to patients.

VU534 Chemical Structure

VU534 Chemical Structure

CAS No. : 923509-20-0

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5 mg USD 105 In-stock
10 mg USD 170 In-stock
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Based on 1 publication(s) in Google Scholar

VU534 Related Antibodies

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Description

VU534 is a NAPE-PLD activator, with an EC50 of 0.30 μM. VU534 is dual inhibitors of FAAH and sEH (IC50 of 1.2 μM). VU534 increases efferocytosis in a NAPE-PLD dependent manner. VU534 has the potential for cardiometabolic diseases study [1] .

IC50 & Target

NAPE-PLD activator, with an EC50 of 0.30 μM
In Vitro

VU534 (up to 30 μM, 24 h) shows minimal cytotoxicity in HepG2 and Raw264.7 cell lines [1].
VU534 (3-30 μM, 1 h) increases NAPE-PLD activity in Raw264.7 cells [1].
VU534 (1 h) increases NAPE-PLD activity in HepG2 cells, with the EC50 values of 1.5 μM[1].
VU534 (5 μM, 1 h) increases NAPE-PLD activity 1.5-fold, but not reverses LEI-401(HY-131181)-inhibited NAPE-PLD activity [1].
VU534 (10 μM, 6 h) significantly enhances efferocytosis in bone-marrow-derived macrophages, but not work in Napepld-/- KO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VU534 Related Antibodies
Molecular Weight

447.55

Formula

C21H22FN3O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(C)=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (55.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2344 mL 11.1719 mL 22.3439 mL
5 mM 0.4469 mL 2.2344 mL 4.4688 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2344 mL 11.1719 mL 22.3439 mL 55.8597 mL
5 mM 0.4469 mL 2.2344 mL 4.4688 mL 11.1719 mL
10 mM 0.2234 mL 1.1172 mL 2.2344 mL 5.5860 mL
15 mM 0.1490 mL 0.7448 mL 1.4896 mL 3.7240 mL
20 mM 0.1117 mL 0.5586 mL 1.1172 mL 2.7930 mL
25 mM 0.0894 mL 0.4469 mL 0.8938 mL 2.2344 mL
30 mM 0.0745 mL 0.3724 mL 0.7448 mL 1.8620 mL
40 mM 0.0559 mL 0.2793 mL 0.5586 mL 1.3965 mL
50 mM 0.0447 mL 0.2234 mL 0.4469 mL 1.1172 mL
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VU534 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU534923509-20-0VU 534VU-534FAAHEpoxide HydrolaseFatty acid amide hydrolaseAtherosclerotic Cardiovascular DiseaseRaw264.7HepG2Bone marrow-derived macrophagesInhibitorinhibitorinhibit

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