2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Cytochrome P450 mAChR
  4. VU6008677

VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P450, exhibits good pharmacokinetic characteristics in rats.

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VU6008677 Chemical Structure

VU6008677 Chemical Structure

CAS No. : 2170550-99-7

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VU6008677 Related Antibodies

Top Publications Citing Use of Products

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

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Description

VU6008677 is a positive allosteric modulator (PAM) for M4, with EC50 of 120 nM for hM4. VU6008677 inhibits cytochrome P450, exhibits good pharmacokinetic characteristics in rats[1].

IC50 & Target

EC50: 120 nM (hM4)
Molecular Weight

288.73

Formula

C14H13ClN4O
CAS No.
SMILES

CC1=C(Cl)C(C)=NC2=C1C3=C(C(NC4CC4)=NC=N3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU6008677 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60086772170550-99-7VU 6008677VU-6008677Cytochrome P450mAChRCYPsMuscarinic acetylcholine receptorallostericPAMInhibitorinhibitorinhibit

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HY-162662
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