2. Immunology/Inflammation
  3. PD-1/PD-L1 CTLA-4
  4. Vudalimab

Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation.

For research use only. We do not sell to patients.

CAS No. : 2329669-72-7

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Based on 1 publication(s) in Google Scholar

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Vudalimab Related Antibodies

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Description

Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation[1].

Isotype

half-IG G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
Species

Chimeric; Humanized
In Vitro

XmAb20717 has binding avidity and contributes to T cell activation, including IL-2, CD45+ cells, and IFNγ[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vudalimab Related Antibodies
In Vivo

XmAb20717 (every two days, for 16 d; NSG mice engrafted with KG1a-luc followed by engraftment with huPBMCs) enhances allogeneic anti-tumor responses in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vudalimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
Purity & Documentation
References
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Vudalimab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vudalimab2329669-72-7PD-1/PD-L1CTLA-4PD-1/Programmed death-ligand 1Cytotoxic T-lymphocyte-associated protein 4CD152humanized monoclonal antibodyT-cellbinding avidityInhibitorinhibitorinhibit

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