2. Immunology/Inflammation
  3. PD-1/PD-L1 CTLA-4
  4. Vudalimab

Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation.

For research use only. We do not sell to patients.

CAS No. : 2329669-72-7

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Based on 1 publication(s) in Google Scholar

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Vudalimab Related Antibodies

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Description

Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation[1].

Isotype

half-IG G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
Species

Chimeric; Humanized
In Vitro

XmAb20717 has binding avidity and contributes to T cell activation, including IL-2, CD45+ cells, and IFNγ[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vudalimab Related Antibodies
In Vivo

XmAb20717 (every two days, for 16 d; NSG mice engrafted with KG1a-luc followed by engraftment with huPBMCs) enhances allogeneic anti-tumor responses in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

146500.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vudalimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
Purity & Documentation
References
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Vudalimab Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vudalimab2329669-72-7PD-1/PD-L1CTLA-4PD-1/Programmed death-ligand 1Cytotoxic T-lymphocyte-associated protein 4CD152humanized monoclonal antibodyT-cellbinding avidityInhibitorinhibitorinhibit

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