2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. WAY-354574

WAY-354574 is an active molecule targeting deacetylase (Sirtuin) for the study of Huntington's disease (HD).

For research use only. We do not sell to patients.

WAY-354574 Chemical Structure

WAY-354574 Chemical Structure

CAS No. : 851873-40-0

Size Price Stock Quantity
5 mg USD 50 In-stock
10 mg USD 80 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

WAY-354574 Related Antibodies

Top Publications Citing Use of Products

View All Sirtuin Isoform Specific Products:

View All Isoforms
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

WAY-354574 is an active molecule targeting deacetylase (Sirtuin) for the study of Huntington's disease (HD)[1].

IC50 & Target

Sirtuin-2 (SIRT2)[1]
Molecular Weight

406.93

Formula

C20H23ClN2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=CC(Cl)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (245.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4574 mL 12.2871 mL 24.5743 mL
5 mM 0.4915 mL 2.4574 mL 4.9149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4574 mL 12.2871 mL 24.5743 mL 61.4356 mL
5 mM 0.4915 mL 2.4574 mL 4.9149 mL 12.2871 mL
10 mM 0.2457 mL 1.2287 mL 2.4574 mL 6.1436 mL
15 mM 0.1638 mL 0.8191 mL 1.6383 mL 4.0957 mL
20 mM 0.1229 mL 0.6144 mL 1.2287 mL 3.0718 mL
25 mM 0.0983 mL 0.4915 mL 0.9830 mL 2.4574 mL
30 mM 0.0819 mL 0.4096 mL 0.8191 mL 2.0479 mL
40 mM 0.0614 mL 0.3072 mL 0.6144 mL 1.5359 mL
50 mM 0.0491 mL 0.2457 mL 0.4915 mL 1.2287 mL
60 mM 0.0410 mL 0.2048 mL 0.4096 mL 1.0239 mL
80 mM 0.0307 mL 0.1536 mL 0.3072 mL 0.7679 mL
100 mM 0.0246 mL 0.1229 mL 0.2457 mL 0.6144 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

WAY-354574 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-354574851873-40-0WAY354574WAY 354574Sirtuin3-(Benzylsulfonamido)benzamidesADMEHuntington's diseasePolyglutamine aggregationSIRT2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
WAY-354574
Cat. No.:
HY-47822
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.