2. PROTAC Apoptosis Epigenetics
  3. PROTACs Apoptosis METTL3
  4. WD6305

WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity.(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

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WD6305 Chemical Structure

WD6305 Chemical Structure

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WD6305 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity[1].(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

IC50 & Target

DC50: 140 nM (METTL3); D max: 91.9% (METTL3) [1]
DC50: 194 nM (METTL14)[1]
In Vitro

WD6305 (20-5000 nM; 24 h) reduces METTL3 protein levels in Mono-Mac-6 cells with a DC50 of 140 nM and a D max of 91.9%[1].
WD6305 (20-5000 nM; 24 h) reduces METTL14 protein levels in Mono-Mac-6 cells with a DC50 of 194 nM[1].
WD6305 (0.5-10 μM; 48 h) decreases the ratio of m6A to polyA mRNA, inhibits cell proliferation and induces cell apoptosis in Mono-Mac-6 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WD6305 Related Antibodies

Western Blot Analysis[1]

Cell Line: Mono-Mac-6 cells
Concentration: 20, 50, 100, 250, 500, 1000, 2000 and 5000 nM
Incubation Time: 24 h
Result: Reduced METTL3 and METTL14 protein levels in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: Mono-Mac-6 cells
Concentration: 1 and 2.5 μM
Incubation Time: 48 h
Result: Increased the levels of cleaved caspase-3 and cleaved PARP.
Molecular Weight

1112.38

Formula

C61H75F2N11O5S
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCC#CC(C=C4)=CC=C4CNC5=CC(N(CC6)CCC76NC(CN(C8=CC(F)=C(CN9CCC(C)(C)CC9)C=C8F)C7)=O)=NC=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WD6305 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WD6305WD 6305WD-6305PROTACsApoptosisMETTL3Methyltransferase-like 3AMLMono-Mac-6 cellsInhibitorinhibitorinhibit

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