2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Werner syndrome RecQ helicase-IN-4

Werner syndrome RecQ helicase-IN-4 

Cat. No.: HY-148741 Purity: 98.13%
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Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity.

For research use only. We do not sell to patients.

Werner syndrome RecQ helicase-IN-4 Chemical Structure

Werner syndrome RecQ helicase-IN-4 Chemical Structure

CAS No. : 2869954-53-8

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10 mg USD 940 In-stock
25 mg USD 1880 In-stock
50 mg USD 3000 In-stock
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Based on 1 publication(s) in Google Scholar

Werner syndrome RecQ helicase-IN-4 Related Antibodies

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Description

Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1].

IC50 & Target

IC50: 0.06 µM (WRN)[1]
In Vitro

Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 µM; 8-20 days) shows antiproliferative activity with GI50s of 0.07, >10 µM for SW48, DLD1 WRN-KO cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Werner syndrome RecQ helicase-IN-4 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SW48, DLD1 WRN-KO cells
Concentration: 0-10 µM
Incubation Time: 8-20 days
Result: Showed antiproliferative activity with GI50s of 0.07, >10 µM for SW48, DLD1 WRN-KO cells, respectively.
In Vivo

Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) shows anticancer activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)[1]
Dosage: 240 mg/kg
Administration: P.o.; daily for 18 days
Result: Inhibited tumor growth.
Molecular Weight

666.65

Formula

C32H33F3N8O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C2=C(CC)N(CC(NC3=CC=C(C(F)(F)F)C=C3C)=O)C4=NC(C5=CCOCC5)=NN4C2=O)C6=NC=CC=C6O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (187.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5000 mL 7.5002 mL 15.0004 mL
5 mM 0.3000 mL 1.5000 mL 3.0001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5000 mL 7.5002 mL 15.0004 mL 37.5009 mL
5 mM 0.3000 mL 1.5000 mL 3.0001 mL 7.5002 mL
10 mM 0.1500 mL 0.7500 mL 1.5000 mL 3.7501 mL
15 mM 0.1000 mL 0.5000 mL 1.0000 mL 2.5001 mL
20 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8750 mL
25 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.5000 mL
30 mM 0.0500 mL 0.2500 mL 0.5000 mL 1.2500 mL
40 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9375 mL
50 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7500 mL
60 mM 0.0250 mL 0.1250 mL 0.2500 mL 0.6250 mL
80 mM 0.0188 mL 0.0938 mL 0.1875 mL 0.4688 mL
100 mM 0.0150 mL 0.0750 mL 0.1500 mL 0.3750 mL
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Werner syndrome RecQ helicase-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Werner syndrome RecQ helicase-IN-42869954-53-8DNA/RNA SynthesisSW48DLD1 WRN-KO cellsantiproliferativeanticancerorally activeInhibitorinhibitorinhibit

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