2. Metabolic Enzyme/Protease Apoptosis Autophagy
  3. Aldose Reductase Mitochondrial Metabolism Apoptosis Mitophagy
  4. WJ-39

WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis.

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WJ-39 Chemical Structure

WJ-39 Chemical Structure

CAS No. : 3009908-95-3

Size Price Stock Quantity
5 mg USD 350 In-stock
10 mg USD 560 In-stock
25 mg USD 1120 In-stock
50 mg USD 1790 In-stock
100 mg USD 2850 In-stock
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Based on 1 publication(s) in Google Scholar

WJ-39 Related Antibodies

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Description

WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis[1].

Molecular Weight

430.32

Formula

C19H14Cl2KNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(N(CC(O[K])=O)C=C(CC2=CC=CC(Cl)=C2Cl)C3=O)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 350 mg/mL (813.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3239 mL 11.6193 mL 23.2385 mL
5 mM 0.4648 mL 2.3239 mL 4.6477 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3239 mL 11.6193 mL 23.2385 mL 58.0963 mL
5 mM 0.4648 mL 2.3239 mL 4.6477 mL 11.6193 mL
10 mM 0.2324 mL 1.1619 mL 2.3239 mL 5.8096 mL
15 mM 0.1549 mL 0.7746 mL 1.5492 mL 3.8731 mL
20 mM 0.1162 mL 0.5810 mL 1.1619 mL 2.9048 mL
25 mM 0.0930 mL 0.4648 mL 0.9295 mL 2.3239 mL
30 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.9365 mL
40 mM 0.0581 mL 0.2905 mL 0.5810 mL 1.4524 mL
50 mM 0.0465 mL 0.2324 mL 0.4648 mL 1.1619 mL
60 mM 0.0387 mL 0.1937 mL 0.3873 mL 0.9683 mL
80 mM 0.0290 mL 0.1452 mL 0.2905 mL 0.7262 mL
100 mM 0.0232 mL 0.1162 mL 0.2324 mL 0.5810 mL
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WJ-39 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WJ-393009908-95-3WJ39WJ 39Aldose ReductaseMitochondrial MetabolismApoptosisMitophagyMitochondrial AutophagyPINK1/Parkinapoptosismitophagydiabetic nephropathytubularInhibitorinhibitorinhibit

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