2. Epigenetics
  3. Histone Methyltransferase
  4. WM-662

WM-662 is a WDR5-MYC interaction inhibitor, with an IC50 of 18 μM. WM-662 has potential for the research of cancer, aging, and neurodegenerative disorders.

For research use only. We do not sell to patients.

WM-662 Chemical Structure

WM-662 Chemical Structure

CAS No. : 1308257-47-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 572 In-stock
Solution
10 mM * 1 mL in DMSO USD 572 In-stock
Solid
5 mg USD 520 In-stock
10 mg USD 845 In-stock
25 mg USD 1700 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

WM-662 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

WM-662 is a WDR5-MYC interaction inhibitor, with an IC50 of 18 μM. WM-662 has potential for the research of cancer, aging, and neurodegenerative disorders[1].

Molecular Weight

415.83

Formula

C19H18ClN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](O[C@@H](CC1=CC=C(C2=CC=CC(Cl)=C2)C=C1)C(NC3=NN=NN3)=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4048 mL 12.0241 mL 24.0483 mL
5 mM 0.4810 mL 2.4048 mL 4.8097 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4048 mL 12.0241 mL 24.0483 mL 60.1207 mL
5 mM 0.4810 mL 2.4048 mL 4.8097 mL 12.0241 mL
10 mM 0.2405 mL 1.2024 mL 2.4048 mL 6.0121 mL
15 mM 0.1603 mL 0.8016 mL 1.6032 mL 4.0080 mL
20 mM 0.1202 mL 0.6012 mL 1.2024 mL 3.0060 mL
25 mM 0.0962 mL 0.4810 mL 0.9619 mL 2.4048 mL
30 mM 0.0802 mL 0.4008 mL 0.8016 mL 2.0040 mL
40 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5030 mL
50 mM 0.0481 mL 0.2405 mL 0.4810 mL 1.2024 mL
60 mM 0.0401 mL 0.2004 mL 0.4008 mL 1.0020 mL
80 mM 0.0301 mL 0.1503 mL 0.3006 mL 0.7515 mL
100 mM 0.0240 mL 0.1202 mL 0.2405 mL 0.6012 mL
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WM-662 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WM-6621308257-47-7WM662WM 662Histone MethyltransferaseWDR5-MYCanceragingneurodegenerativeInhibitorinhibitorinhibit

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