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Xanthinol Nicotinate  (Synonyms: Xanthinol Niacinate)

Cat. No.: HY-B1815 Purity: 99.93%
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Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance.

For research use only. We do not sell to patients.

Xanthinol Nicotinate Chemical Structure

Xanthinol Nicotinate Chemical Structure

CAS No. : 437-74-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in Water USD 66 In-stock
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100 mg USD 105 In-stock
250 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Xanthinol Nicotinate:

Xanthinol Nicotinate Related Antibodies

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Description

Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2].

In Vitro

Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 µM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner[2].
Xanthinol Nicotinate (2.76-276 µM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthinol Nicotinate Related Antibodies

Cell Proliferation Assay[2]

Cell Line: human umbilical artery smooth muscle cell (HUASMC)
Concentration: 2.76, 27.6 or 276 µM
Incubation Time: for 24 hours
Result: Inhibited HUASMC proliferation in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: HUASMC
Concentration: 2.76, 27.6 or 276 µM
Incubation Time: for 24 hours
Result: Dose-dependently decreased the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs.
In Vivo

Xanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration[1].
Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors (enhancement in radiation response of 1.4)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 week-old male NMRI mice[1]
Dosage: 75 mg/kg
Administration: IP
Result: Rapidly and transiently modified tumor pO2 and Maximal pO2 values were obtained 10 to 30 minutes after XN administration.
Molecular Weight

434.45

Formula

C19H26N6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CN=C1)O.O=C(N2C)N(C)C3=C(N(CC(O)CN(CCO)C)C=N3)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (575.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3018 mL 11.5088 mL 23.0176 mL
5 mM 0.4604 mL 2.3018 mL 4.6035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (115.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3018 mL 11.5088 mL 23.0176 mL 57.5440 mL
5 mM 0.4604 mL 2.3018 mL 4.6035 mL 11.5088 mL
10 mM 0.2302 mL 1.1509 mL 2.3018 mL 5.7544 mL
15 mM 0.1535 mL 0.7673 mL 1.5345 mL 3.8363 mL
20 mM 0.1151 mL 0.5754 mL 1.1509 mL 2.8772 mL
25 mM 0.0921 mL 0.4604 mL 0.9207 mL 2.3018 mL
30 mM 0.0767 mL 0.3836 mL 0.7673 mL 1.9181 mL
40 mM 0.0575 mL 0.2877 mL 0.5754 mL 1.4386 mL
50 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1509 mL
60 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9591 mL
80 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7193 mL
100 mM 0.0230 mL 0.1151 mL 0.2302 mL 0.5754 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Xanthinol Nicotinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthinol Nicotinate437-74-1Xanthinol NiacinateOthersvasodilatorsmoothmusclearteriescapillariesbloodvesselsrheologyperipheralvascularresistanceHUASMCInhibitorinhibitorinhibit

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