Xerophilusin A

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Xerophilusin A, a ent-kaurane diterpenoid, can be isolated from the aerial parts of Isodon enanderianus.

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Xerophilusin A Chemical Structure

CAS No. : 272459-37-7

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Description

Xerophilusin A, a ent-kaurane diterpenoid, can be isolated from the aerial parts of Isodon enanderianus^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	> 10 μM Compound: 30	Cytotoxicity against human HepG2 cells after 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs	[PMID: 17665952]
HL-60	IC₅₀	0.45 μg/mL Compound: 1, xerophilusin A	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 10843567]
K562	IC₅₀	1.6 μM Compound: 30	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 17665952]
K562	IC₅₀	2.22 μg/mL Compound: 1, xerophilusin A	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 10843567]
MKN-28	IC₅₀	0.12 μg/mL Compound: 1, xerophilusin A	Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay	[PMID: 10843567]
MKN-45	IC₅₀	> 10 μM Compound: 30	Cytotoxicity against human MKN45 cells after 48 hrs Cytotoxicity against human MKN45 cells after 48 hrs	[PMID: 17665952]
RAW264.7	IC₅₀	0.6 μM Compound: 1	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method	[PMID: 19719246]
RAW264.7	IC₅₀	1.8 μM Compound: 1	Inhibition of NF-kappaB activation in LPS-stimulated mouse RAW264.7 cells assessed as relative luciferase activity after 24 hrs by dual reporter gene assay Inhibition of NF-kappaB activation in LPS-stimulated mouse RAW264.7 cells assessed as relative luciferase activity after 24 hrs by dual reporter gene assay	[PMID: 19719246]
RAW264.7	IC₅₀	11.3 μM Compound: 1	Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 19719246]

Molecular Weight

404.45

Formula

C₂₂H₂₈O₇

CAS No.

272459-37-7

SMILES

O[C@@]12[C@]34[C@]5([H])[C@]6([C@](C(C)(CCC6)C)([H])[C@@H]2O)[C@@](O1)([H])O[C@@]3([H])[C@](C[C@H]5OC(C)=O)([H])C(C4=O)=C

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Na Z, et al. Diterpenoids from Isodon enanderianus. Phytochemistry, 2002, 60(1): 55-60.

Xerophilusin A Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Xerophilusin A272459-37-7OthersInhibitorinhibitorinhibit

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