Xerophilusin B

Cat. No.: HY-N11050: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis.

For research use only. We do not sell to patients.

Xerophilusin B Chemical Structure

CAS No. : 167894-15-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2 μM Compound: 21	Cytotoxicity against human A549 cells after 48 hrs by MTT method Cytotoxicity against human A549 cells after 48 hrs by MTT method	[PMID: 21534539]
HepG2	IC₅₀	3.9 μM Compound: 27	Cytotoxicity against human HepG2 cells after 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs	[PMID: 17665952]
HL-60	IC₅₀	0.29 μg/mL Compound: 2, xerophilusin B	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 10843567]
HL-60	IC₅₀	0.8 μM Compound: 21	Cytotoxicity against human HL60 cells after 48 hrs by MTT method Cytotoxicity against human HL60 cells after 48 hrs by MTT method	[PMID: 21534539]
K562	IC₅₀	0.73 μg/mL Compound: 2, xerophilusin B	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 10843567]
K562	IC₅₀	4.1 μM Compound: 27	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 17665952]
MCF7	IC₅₀	1.1 μM Compound: 21	Cytotoxicity against human MCF7 cells after 48 hrs by MTT method Cytotoxicity against human MCF7 cells after 48 hrs by MTT method	[PMID: 21534539]
MKN-28	IC₅₀	0.17 μg/mL Compound: 2, xerophilusin B	Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells after 48 hrs by MTT assay	[PMID: 10843567]
MKN-45	IC₅₀	0.4 μM Compound: 27	Cytotoxicity against human MKN45 cells after 48 hrs Cytotoxicity against human MKN45 cells after 48 hrs	[PMID: 17665952]
RAW264.7	IC₅₀	0.225 μM Compound: 2	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method	[PMID: 19719246]
RAW264.7	IC₅₀	0.7 μM Compound: 2	Inhibition of NF-kappaB activation in LPS-stimulated mouse RAW264.7 cells assessed as relative luciferase activity after 24 hrs by dual reporter gene assay Inhibition of NF-kappaB activation in LPS-stimulated mouse RAW264.7 cells assessed as relative luciferase activity after 24 hrs by dual reporter gene assay	[PMID: 19719246]
RAW264.7	IC₅₀	10.1 μM Compound: 2	Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 19719246]
SMMC-7721	IC₅₀	1.3 μM Compound: 21	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT method Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT method	[PMID: 21534539]
SW480	IC₅₀	0.9 μM Compound: 21	Cytotoxicity against human SW480 cells after 48 hrs by MTT method Cytotoxicity against human SW480 cells after 48 hrs by MTT method	[PMID: 21534539]

Molecular Weight

346.42

Formula

C₂₀H₂₆O₅

CAS No.

167894-15-7

SMILES

O[C@]12[C@]34[C@]5([H])[C@@]6(C(O[C@@]3([H])[C@](CC5)([H])C(C4=O)=C)([H])O2)[C@](C(C)(CCC6)C)([H])[C@@H]1O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ran Yao, et al. Xerophilusin B induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma cells and does not cause toxicity in nude mice. J Nat Prod. 2015 Jan 23;78(1):10-6. [Content Brief]

Xerophilusin B Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xerophilusin B167894-15-7ApoptosisIsodon xerophilusESCCapoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks