XIAP degrader-1

Cat. No.: HY-115865 Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions

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XIAP degrader-1, a primary amine tethered small molecule, promotes the degradation of X-linked inhibitor of apoptosis protein (XIAP).

For research use only. We do not sell to patients.

XIAP degrader-1 Chemical Structure

CAS No. : 2803617-91-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 715	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 715	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3350	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5400	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE XIAP degrader-1

•Nat Commun. 2024 Jun 26;15(1):5409. [Abstract]

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cIAP cIAP-1 cIAP-2 XIAP

Biological Activity
Purity & Documentation
References
Customer Review

Description

XIAP degrader-1, a primary amine tethered small molecule, promotes the degradation of X-linked inhibitor of apoptosis protein (XIAP).

Molecular Weight

587.75

Formula

C₃₄H₄₅N₅O₄

CAS No.

2803617-91-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

CN[C@H](C(N[C@@H]1C(N(C2=C(N([C@H]1C)C(CCCCCCCN)=O)C=CC=C2)CC3=C(C=CC=C4)C4=CC=C3OC)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (170.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7014 mL	8.5070 mL	17.0140 mL
5 mM	0.3403 mL	1.7014 mL	3.4028 mL
10 mM	0.1701 mL	0.8507 mL	1.7014 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (252 KB) HNMR (269 KB) RP-HPLC (381 KB)

Handling Instructions (2659 KB)

References

[1]. den Besten W, et al. Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein. J Am Chem Soc. 2021 Jul 21;143(28):10571-10575. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7014 mL	8.5070 mL	17.0140 mL	42.5351 mL
	5 mM	0.3403 mL	1.7014 mL	3.4028 mL	8.5070 mL
	10 mM	0.1701 mL	0.8507 mL	1.7014 mL	4.2535 mL
	15 mM	0.1134 mL	0.5671 mL	1.1343 mL	2.8357 mL
	20 mM	0.0851 mL	0.4254 mL	0.8507 mL	2.1268 mL
	25 mM	0.0681 mL	0.3403 mL	0.6806 mL	1.7014 mL
	30 mM	0.0567 mL	0.2836 mL	0.5671 mL	1.4178 mL
	40 mM	0.0425 mL	0.2127 mL	0.4254 mL	1.0634 mL
	50 mM	0.0340 mL	0.1701 mL	0.3403 mL	0.8507 mL
	60 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7089 mL
	80 mM	0.0213 mL	0.1063 mL	0.2127 mL	0.5317 mL
	100 mM	0.0170 mL	0.0851 mL	0.1701 mL	0.4254 mL

XIAP degrader-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XIAP degrader-12803617-91-4XIAP degrader1XIAP degrader 1IAPInhibitorinhibitorinhibit

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XIAP degrader-1

Customer Review

XIAP degrader-1 Related Antibodies

1 Publications Citing Use of MCE XIAP degrader-1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All IAP Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

XIAP degrader-1 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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