2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain Histone Acetyltransferase
  4. XYD129

XYD129 is an effective CBP/p300 PROTAC degrader. XYD129 has antiproliferative activity on MV4-11 cell line (IC 50=0.044 μM). XYD129 can be used for the study of acute myeloid leukemia (AML). (Structure Note: Pink, CBP/p300 ligand 5 (HY-161711); Blue, E3 ligase ligand (HY-41547); Black, Linker (HY-40178)).

For research use only. We do not sell to patients.

XYD129 Chemical Structure

XYD129 Chemical Structure

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Description

XYD129 is an effective CBP/p300 PROTAC degrader. XYD129 has antiproliferative activity on MV4-11 cell line (IC 50=0.044 μM). XYD129 can be used for the study of acute myeloid leukemia (AML). (Structure Note: Pink, CBP/p300 ligand 5 (HY-161711); Blue, E3 ligase ligand (HY-41547); Black, Linker (HY-40178))[1].

Molecular Weight

806.79

Formula

C41H39FN8O9
SMILES

O=C(C1=CC(C(NC2=C(C(C3=CN(N=C3)C)=CC(CO)=C2)F)=O)=C4N1C=CC(OCC(NCCCCNC5=CC=CC6=C5C(N(C7CCC(NC7=O)=O)C6=O)=O)=O)=C4)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XYD129 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

XYD129XYD 129XYD-129PROTACsEpigenetic Reader DomainHistone AcetyltransferaseHATsHATTumor suppressor activityAMLPROTACCBPp300Inhibitorinhibitorinhibit

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