2. Metabolic Enzyme/Protease
  3. HIV Integrase
  4. XZ426

XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity.

For research use only. We do not sell to patients.

XZ426 Chemical Structure

XZ426 Chemical Structure

CAS No. : 1638504-52-5

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Based on 1 publication(s) in Google Scholar

XZ426 Related Antibodies

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Description

XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity[1].

In Vitro

Intasomes are the target of the latest generation of antiretroviral drugs, integrase (IN) strand transfer inhibitors (INSTI). To better understand how INSTIs interact with HIV intasomes, we assembled the complex with bictegravir (BIC), the leading second-generation INSTI and the most broadly effective of all clinically approved INSTIs. Among these, XZ426 is a lead candidate that has shown superior efficacy to all clinically used and developed compounds against known drug-resistant variants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XZ426 Related Antibodies
Molecular Weight

446.45

Formula

C22H24F2N4O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(N)C2=C(N=CC(CCCCCCO)=C2)N(O)C1=O)NCC3=CC=C(C=C3F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (223.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2399 mL 11.1995 mL 22.3989 mL
5 mM 0.4480 mL 2.2399 mL 4.4798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

SDS (251 KB)

COA (244 KB) HNMR (264 KB) RP-HPLC (359 KB) LCMS (393 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2399 mL 11.1995 mL 22.3989 mL 55.9973 mL
5 mM 0.4480 mL 2.2399 mL 4.4798 mL 11.1995 mL
10 mM 0.2240 mL 1.1199 mL 2.2399 mL 5.5997 mL
15 mM 0.1493 mL 0.7466 mL 1.4933 mL 3.7332 mL
20 mM 0.1120 mL 0.5600 mL 1.1199 mL 2.7999 mL
25 mM 0.0896 mL 0.4480 mL 0.8960 mL 2.2399 mL
30 mM 0.0747 mL 0.3733 mL 0.7466 mL 1.8666 mL
40 mM 0.0560 mL 0.2800 mL 0.5600 mL 1.3999 mL
50 mM 0.0448 mL 0.2240 mL 0.4480 mL 1.1199 mL
60 mM 0.0373 mL 0.1867 mL 0.3733 mL 0.9333 mL
80 mM 0.0280 mL 0.1400 mL 0.2800 mL 0.7000 mL
100 mM 0.0224 mL 0.1120 mL 0.2240 mL 0.5600 mL
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XZ426 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XZ4261638504-52-5XZ 426XZ-426HIV IntegraseHIVintegrasestrand transfer inhibitorInhibitorinhibitorinhibit

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