2. Membrane Transporter/Ion Channel
  3. Piezo Channel
  4. Yaddle1

Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants.

For research use only. We do not sell to patients.

Yaddle1 Chemical Structure

Yaddle1 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Yaddle1 Related Antibodies

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Description

Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants[1].

In Vitro

Yaddle1 (Compound 34) (0.1-20 μM; 6-24 h) has no significant toxicity to PBMCs cells[1].
Yaddle1 (Compound 34) (200 μM；24 h) has a kinetic solubility of 26.72 μM at pH 7.4, which is 10-fold better than that of Yoda1(HY-18723)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Yaddle1 Related Antibodies
Molecular Weight

372.75

Formula

C14H8ClF3N4OS
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(CSC2=NN=C(C3=NC=CN=C3)O2)C(C(F)(F)F)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (268.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6828 mL 13.4138 mL 26.8276 mL
5 mM 0.5366 mL 2.6828 mL 5.3655 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6828 mL 13.4138 mL 26.8276 mL 67.0691 mL
5 mM 0.5366 mL 2.6828 mL 5.3655 mL 13.4138 mL
10 mM 0.2683 mL 1.3414 mL 2.6828 mL 6.7069 mL
15 mM 0.1789 mL 0.8943 mL 1.7885 mL 4.4713 mL
20 mM 0.1341 mL 0.6707 mL 1.3414 mL 3.3535 mL
25 mM 0.1073 mL 0.5366 mL 1.0731 mL 2.6828 mL
30 mM 0.0894 mL 0.4471 mL 0.8943 mL 2.2356 mL
40 mM 0.0671 mL 0.3353 mL 0.6707 mL 1.6767 mL
50 mM 0.0537 mL 0.2683 mL 0.5366 mL 1.3414 mL
60 mM 0.0447 mL 0.2236 mL 0.4471 mL 1.1178 mL
80 mM 0.0335 mL 0.1677 mL 0.3353 mL 0.8384 mL
100 mM 0.0268 mL 0.1341 mL 0.2683 mL 0.6707 mL
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Yaddle1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yaddle1Yaddle 1Yaddle-1Piezo Channelhuman CD4+ T cellPBMCsvaccine adjuvantInhibitorinhibitorinhibit

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