YNT-185 dihydrochloride

Name: YNT-185 dihydrochloride
Brand: MedChemExpress
SKU: HY-136181
Rating: 4.5 (1 reviews)

Cat. No.: HY-136181 Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

For research use only. We do not sell to patients.

YNT-185 dihydrochloride Chemical Structure

CAS No. : 1804978-82-2

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 930	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of YNT-185 dihydrochloride:

YNT-185 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Orexin Receptor (OX Receptor) Isoform Specific Products:

View All Isoforms

OX₂ Receptor OX₁ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

OX₂ Receptor

0.028 μM (EC₅₀)

OX₁ Receptor

2.75 μM (EC₅₀)

In Vivo

YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice^[2].
YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male wild-type C57BL/6J mice^[2]
Dosage:	20, 40 mg/kg
Administration:	I.p.
Result:	Wake time was also significantly increased.

Molecular Weight

688.66

Formula

C₃₃H₃₉Cl₂N₅O₅S

CAS No.

1804978-82-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=[S](NC1=CC(NCCNC(C(C=CC=C2)=C2N(C)C)=O)=CC=C1)(C(C=C(C3=CC(C(N(C)C)=O)=CC=C3)C=C4)=C4OC)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (181.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (145.21 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4521 mL	7.2605 mL	14.5210 mL
5 mM	0.2904 mL	1.4521 mL	2.9042 mL
10 mM	0.1452 mL	0.7260 mL	1.4521 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline
Solubility: 12.5 mg/mL (18.15 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (129 KB) RP-HPLC (244 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)

References

[1]. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937. [Content Brief]

[2]. Irukayama-Tomobe Y, et al. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 2017;114(22):5731-5736. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.4521 mL	7.2605 mL	14.5210 mL	36.3024 mL
	5 mM	0.2904 mL	1.4521 mL	2.9042 mL	7.2605 mL
	10 mM	0.1452 mL	0.7260 mL	1.4521 mL	3.6302 mL
	15 mM	0.0968 mL	0.4840 mL	0.9681 mL	2.4202 mL
	20 mM	0.0726 mL	0.3630 mL	0.7260 mL	1.8151 mL
	25 mM	0.0581 mL	0.2904 mL	0.5808 mL	1.4521 mL
	30 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2101 mL
	40 mM	0.0363 mL	0.1815 mL	0.3630 mL	0.9076 mL
	50 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7260 mL
	60 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6050 mL
	80 mM	0.0182 mL	0.0908 mL	0.1815 mL	0.4538 mL
	100 mM	0.0145 mL	0.0726 mL	0.1452 mL	0.3630 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.