2. PROTAC Autophagy
  3. AUTOTACs p62
  4. YTK-105

YTK-105 is a ligand of p62-ZZ domain. YTK-105 can activate p62-dependent selective macroautophagy. YTK-105 can be used for AUTOTAC design.

For research use only. We do not sell to patients.

YTK-105 Chemical Structure

YTK-105 Chemical Structure

CAS No. : 774192-20-0

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5 mg USD 75 In-stock
10 mg USD 120 In-stock
25 mg USD 240 In-stock
50 mg USD 385 In-stock
100 mg USD 615 In-stock
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Based on 1 publication(s) in Google Scholar

YTK-105 Related Antibodies

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Description

YTK-105 is a ligand of p62-ZZ domain. YTK-105 can activate p62-dependent selective macroautophagy. YTK-105 can be used for AUTOTAC design[1].

Molecular Weight

257.33

Formula

C16H19NO2
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

OCCNCC1=CC=CC(OCC2=CC=CC=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (680.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8861 mL 19.4303 mL 38.8606 mL
5 mM 0.7772 mL 3.8861 mL 7.7721 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8861 mL 19.4303 mL 38.8606 mL 97.1515 mL
5 mM 0.7772 mL 3.8861 mL 7.7721 mL 19.4303 mL
10 mM 0.3886 mL 1.9430 mL 3.8861 mL 9.7152 mL
15 mM 0.2591 mL 1.2954 mL 2.5907 mL 6.4768 mL
20 mM 0.1943 mL 0.9715 mL 1.9430 mL 4.8576 mL
25 mM 0.1554 mL 0.7772 mL 1.5544 mL 3.8861 mL
30 mM 0.1295 mL 0.6477 mL 1.2954 mL 3.2384 mL
40 mM 0.0972 mL 0.4858 mL 0.9715 mL 2.4288 mL
50 mM 0.0777 mL 0.3886 mL 0.7772 mL 1.9430 mL
60 mM 0.0648 mL 0.3238 mL 0.6477 mL 1.6192 mL
80 mM 0.0486 mL 0.2429 mL 0.4858 mL 1.2144 mL
100 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.9715 mL
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YTK-105 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YTK-105774192-20-0YTK105YTK 105AUTOTACsp62AUTOphagy-TArgeting ChimerasSequestosome-1SQSTM1U87-MG cellsHeLa cellsautophagyAUTOTACInhibitorinhibitorinhibit

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